Byrnes Kurt, Ford Andriana, Bennie Nick
NCCI, Lismore Base Hospital, Northern NSW Local Health District, Lismore, NSW, 2480, Australia.
Australas Phys Eng Sci Med. 2019 Jun;42(2):639-645. doi: 10.1007/s13246-019-00749-2. Epub 2019 Mar 12.
Many studies have performed dosimetric studies using various metal implants however these are difficult to translate to other implants of a different geometry or material (Rijken and Colyer, J Appl Clin Med Phys 18:5:301-306, 2017; Ade and du Plessis, J Appl Clin Med Phys 18:5:162-173, 2017; Prabhakar et al. Rep Pract Oncol Radiother 18:209-213, 2013; Ng et al. Rep Pract Oncol Radiother 20:273-277, 2015; Reft et al. Med Phys 30:1162-1182, 2003; Sasaki et al., Nihon Hoshasen Gijutsu Gakkai Zasshi 72(9):735-745, 2016). In this study, the ability of the Monaco Monte Carlo algorithm (Elekta AB, Stockholm, Sweden) to model radiation transport through different types of metals was evaluated. Investigation of the capabilities and limitations of the algorithm is required for the potential use of Monaco for planning radiotherapy treatments when avoidance of metal implants is clinically undesirable. A MapCHECK 2 diode array (Sun Nuclear Corp, Melbourne, USA) and a PTW 30013 Farmer chamber was used to measure the dose at depth, downstream of 1 cm × 5 cm × 5 cm metal blocks of three known compositions; stainless steel, aluminium and MCP96. The setup was imaged using a CT scanner and imported into the Monaco TPS where the beam arrangement was replicated. The density of the metals was overridden using the known electron density of each (IMPAC Medical Systems Inc, Monaco dose calculation technical reference. IMPAC Medical Systems, Sunnydale, CA, 2013). The differences between the dose measured using the ion chamber and calculated using Monaco downstream of the 1 cm metal blocks were respectively: - 1.2%, - 2.2% and 9.5% when irradiated using a 6 MV beam, and - 0.9%, - 1.3% and 14%, when irradiated using a 15 MV beam. This was then repeated using 2 cm and 3 cm of each metal type giving similar results for aluminium and stainless steel and increased discrepancy for MCP96. Discrepancies between treatment planning software and measurements at depth have been shown to give uncertainties between 5 and 23% in previous studies (Rijken and Colyer, J Appl Clin Med Phys 18:5:301-306, 2017; Ade and du Plessis, J Appl Clin Med Phys 18:5:162-173, 2017; Prabhakar et al. Rep Pract Oncol Radiother 18:209-213, 2013; Ng et al. Rep Pract Oncol Radiother 20:273-277, 2015; Reft et al. Med Phys 30:1162-1182, 2003; Sasaki et al., Nihon Hoshasen Gijutsu Gakkai Zasshi 72(9):735-745, 2016). This study uses basic shapes providing results that remove the uncertainties in geometry and can therefore be applied to any shape. This will help determine whether errors in dose calculations are due to the TPS particle transport algorithms or due to other effects, such as inaccurate contouring or incorrect densities. Thus giving the planner an additional degree of freedom in their planning and decision making process.
许多研究使用各种金属植入物进行了剂量学研究,然而,这些研究很难应用于具有不同几何形状或材料的其他植入物(Rijken和Colyer,《应用临床医学生物物理学》18:5:301 - 306,2017;Ade和du Plessis,《应用临床医学生物物理学》18:5:162 - 173,2017;Prabhakar等人,《肿瘤放射治疗实践报告》18:209 - 213,2013;Ng等人,《肿瘤放射治疗实践报告》20:273 - 277,2015;Reft等人,《医学物理》30:1162 - 1182,2003;Sasaki等人,《日本放射学会杂志》72(9):735 - 745,2016)。在本研究中,评估了Monaco蒙特卡罗算法(瑞典斯德哥尔摩Elekta AB公司)对不同类型金属中辐射传输进行建模的能力。当临床上不希望避开金属植入物时,若要将Monaco用于放射治疗计划,就需要研究该算法的能力和局限性。使用MapCHECK 2二极管阵列(美国墨尔本Sun Nuclear Corp公司)和PTW 30013 Farmer电离室来测量在三种已知成分(不锈钢、铝和MCP96)的1 cm×5 cm×5 cm金属块下游深度处的剂量。使用CT扫描仪对设置进行成像,并导入Monaco治疗计划系统(TPS),在其中复制射束排列。利用每种金属已知的电子密度(IMPAC医疗系统公司,Monaco剂量计算技术参考。IMPAC医疗系统,加利福尼亚州森尼戴尔,2013)覆盖金属的密度。在1 cm金属块下游,使用电离室测量的剂量与使用Monaco计算的剂量之间的差异分别为:使用6 MV射束照射时为 - 1.2%、 - 2.2%和9.5%,使用15 MV射束照射时为 - 0.9%、 - 1.3%和14%。然后对每种金属类型的2 cm和3 cm厚度重复此操作,铝和不锈钢得到类似结果,而MCP96的差异增大。在先前的研究中,已表明治疗计划软件与深度处测量值之间的差异会导致5%至23%的不确定性(Rijken和Colyer,《应用临床医学生物物理学》18:5:301 - 306,2017;Ade和du Plessis,《应用临床医学生物物理学》18:5:162 - 173,2017;Prabhakar等人,《肿瘤放射治疗实践报告》18:209 - 213,2013;Ng等人,《肿瘤放射治疗实践报告》20:273 - 277,2015;Reft等人,《医学物理》30:1162 - 118