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一例具有乳头状形态的中枢神经系统孤立性纤维瘤/血管外皮细胞瘤。

A case of solitary fibrous tumor/hemangiopericytoma in the central nervous system with papillary morphology.

作者信息

Cao Lijuan, Zhang Xialing, Wang Yin, Bao Yun, Tang Feng

机构信息

Department of Pathology, Huashan Hospital of Fudan University, Shanghai, China.

出版信息

Neuropathology. 2019 Apr;39(2):141-146. doi: 10.1111/neup.12541. Epub 2019 Mar 12.

Abstract

This report describes the clinicopathological findings of a solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) of the central nervous system in a 59-year-old man with space-occupying lesions on both the left anterior basicranial and on the top tail of falx cerebri. The tumor showed small quantities of solid papillary areas and a prominent papillary structure, where atypical cells were compactly arranged along the fibrovascular core. The tumor cells of both components showed nuclear relocalization of the signal transducer and activator of transcription 6 protein, with very high specificity and sensitivity for the diagnosis of SFT/HPC. In the literature, only three cases of SFTs with a papillary pattern have been reported, but this case showed a complete papillary pattern. "Papillary" SFT/HPC is a rare morphological variant of SFTs/HPCs, and its differential diagnosis among intracranial tumors is an important factor which clinicians should bear in mind during diagnosis.

摘要

本报告描述了一名59岁男性中枢神经系统孤立性纤维瘤(SFT)/血管外皮细胞瘤(HPC)的临床病理特征,该患者左前颅底和大脑镰顶部尾端均有占位性病变。肿瘤呈现少量实性乳头区域及显著的乳头结构,非典型细胞沿纤维血管核心紧密排列。两种成分的肿瘤细胞均显示信号转导和转录激活因子6蛋白的核重新定位,对SFT/HPC的诊断具有很高的特异性和敏感性。文献中仅报道了3例具有乳头型的SFT,但该病例呈现出完整的乳头型。“乳头型”SFT/HPC是SFTs/HPCs一种罕见的形态学变异,其在颅内肿瘤中的鉴别诊断是临床医生在诊断过程中应牢记的重要因素。

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