研究信号转导和转录激活因子4（STAT4）基因多态性与类风湿性关节炎易感性之间的关联：一项更新的荟萃分析。
Studying the Association between STAT4 Gene Polymorphism and Susceptibility to Rheumatoid Arthritis Disease: An Updated Meta-Analysis.
作者信息
Ebrahimiyan Hamidreza, Mostafaei Shayan, Aslani Saeed, Jamshidi Ahmadreza, Mahmoudi Mahdi
机构信息
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Immunol. 2019 Mar;16(1):71-83. doi: 10.22034/IJI.2019.39408.
BACKGROUND
STAT4 is a transcription factor that plays a role in various cytokine signaling pathways and in T cell subsets differentiation. Several studies have reported STAT4 gene polymorphism in association with various autoimmune diseases.
OBJECTIVE
To evaluated the association between STAT4 rs7574865 SNP and RA risk by meta-analysis.
METHODS
Two major databases, namely Scopus and PubMed, were searched to find studies investigating the STAT4 polymorphism and RA in different populations up to November 2017. Association between STAT4 polymorphism and RA were analyzed using pooled odds ratio (OR) and their corresponding 95% CI.
RESULTS
In this meta-analysis, 21 population studies (16 papers) comprising 15,732 cases and 15641 healthy subjects evaluating the STAT4 gene rs7574865 SNP were included based on inclusion criteria. Herein, we found a significant positive association between minor T allele as well as different genotypes with the risk of RA.
CONCLUSIONS
In summary, this study revealed an association between STAT4 gene rs7574865 SNP and risk of RA.
背景
信号转导和转录激活因子4（STAT4）是一种转录因子，在多种细胞因子信号通路及T细胞亚群分化中发挥作用。多项研究报道了STAT4基因多态性与多种自身免疫性疾病相关。
目的
通过荟萃分析评估STAT4基因rs7574865单核苷酸多态性（SNP）与类风湿关节炎（RA）风险之间的关联。
方法
检索两个主要数据库，即Scopus和PubMed，以查找截至2017年11月在不同人群中研究STAT4多态性与RA的研究。使用合并比值比（OR）及其相应的95%置信区间（CI）分析STAT4多态性与RA之间的关联。
结果
在这项荟萃分析中，根据纳入标准纳入了21项人群研究（16篇论文），共15732例患者和15641名健康受试者，评估了STAT4基因rs7574865 SNP。在此，我们发现次要T等位基因以及不同基因型与RA风险之间存在显著正相关。
结论
总之，本研究揭示了STAT4基因rs7574865 SNP与RA风险之间的关联。
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