Music Arif, Baumann Andreas N, Spieß Philipp, Hilgert Nicolas, Köllen Martin, Didier Dorian
Department of Chemistry and Pharmacy , Ludwig-Maximilians-Universität München , Butenandtstraße 5-13 , 81377 Munich , Germany.
Org Lett. 2019 Apr 5;21(7):2189-2193. doi: 10.1021/acs.orglett.9b00493. Epub 2019 Mar 13.
Zweifel olefination is a catalyst-free reaction that serves alkene functionalization. While most methods employ commercially available boron pinacol esters, we have assembled a sequence in which the two partners of the formal coupling reaction are installed successively, starting from inexpensive boron alkoxides. The in situ formation of bisorganoborinates was accomplished by consecutive reaction of two different organometallic species. This single-pot procedure represents a great advancement in the generation of organoborinates and their involvement in C-C bond formation.
茨维费尔烯化反应是一种无催化剂的用于烯烃官能化的反应。虽然大多数方法使用市售的硼酸频哪醇酯，但我们设计了一种反应序列，其中形式上的偶联反应的两个反应物从廉价的硼醇盐开始依次引入。双有机硼酸酯的原位形成是通过两种不同有机金属物种的连续反应实现的。这种一锅法在有机硼酸酯的生成及其参与碳 - 碳键形成方面代表了一项重大进展。
