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大麻素对大脑的有益和有害影响：超低剂量 THC 的案例。

Beneficial and deleterious effects of cannabinoids in the brain: the case of ultra-low dose THC.

机构信息

Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

Am J Drug Alcohol Abuse. 2019;45(6):551-562. doi: 10.1080/00952990.2019.1578366. Epub 2019 Mar 13.

DOI:10.1080/00952990.2019.1578366
PMID:30864864
Abstract

This article reviews the neurocognitive advantages and drawbacks of cannabinoid substances, and discusses the possible physiological mechanisms that underlie their dual activity. The article further reviews the neurocognitive effects of ultra-low doses of ∆9-tetrahydrocannabinol (THC; 3-4 orders of magnitude lower than the conventional doses) in mice, and proposes such low doses of THC as a possible remedy for various brain injuries and for the treatment of age-related cognitive decline.

摘要

本文综述了大麻素物质的神经认知优势和缺陷，并讨论了其双重作用可能的生理机制。文章还进一步综述了超低剂量的 ∆9-四氢大麻酚（THC；比常规剂量低 3-4 个数量级）对小鼠的神经认知影响，并提出将这种低剂量的 THC 作为治疗各种脑损伤和治疗与年龄相关的认知能力下降的可能方法。

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