Flamm R E, Harris-Warrick R M
J Neurophysiol. 1986 May;55(5):847-65. doi: 10.1152/jn.1986.55.5.847.
We investigated the effects of dopamine, octopamine, and serotonin on the motor output of the pyloric circuit in the stomatogastric ganglion of the lobster, Panulirus interruptus. Amines were bath applied at concentrations from 10(-8) to 10(-4) M, and the responses of the six classes of pyloric neurons were monitored both intracellularly and extracellularly. Each amine modified the pyloric motor pattern in a specific way. In addition, dopamine and octopamine were each able to produce different motor patterns at different concentrations. Amine effects on pyloric neurons included initiation and enhancement or inhibition of spike activity, changes in the phase relationships of neurons, and changes in the cycle frequency of the pyloric rhythm. These results show that the motor pattern produced by this well-studied central pattern generator circuit is highly plastic and can be modulated by endogenous biogenic amines.
我们研究了多巴胺、章鱼胺和5-羟色胺对断沟龙虾（Panulirus interruptus）口胃神经节幽门回路运动输出的影响。将胺类物质以10⁻⁸至10⁻⁴ M的浓度进行浴槽给药，并在细胞内和细胞外监测六类幽门神经元的反应。每种胺类物质都以特定方式改变幽门运动模式。此外，多巴胺和章鱼胺在不同浓度下都能够产生不同的运动模式。胺类物质对幽门神经元的影响包括引发和增强或抑制动作电位活动、改变神经元的相位关系以及改变幽门节律的周期频率。这些结果表明，由这个经过充分研究的中枢模式发生器回路产生的运动模式具有高度可塑性，并且可以被内源性生物胺调节。
