Sensitivity to DNA-damaging agents and mutation induction by UV light in UV-sensitive CHO cells.
作者信息
Stefanini M, Mondello C, Tessera L, Capuano V, Guerra B R, Nuzzo F
出版信息
Mutat Res. 1986 Jun;174(2):155-9. doi: 10.1016/0165-7992(86)90108-9.
PMID:3086715
Abstract
Three UV-sensitive (UVs) mutants isolated from a CHO cell line were analyzed for survival after exposure to H2O2, EMS, MMC, CCNU, X-rays and for mutation induction after UV-irradiation. The UVs mutants showed normal sensitivities to EMS and H2O2, whereas they were hypersensitive to the bifunctional alkylating agents MMC and CCNU and to hypoxic X-irradiation. Compared to parental cells, one of the UV-sensitive clones showed approximately 3- and 7-fold enhancement in the mutagenic response per unit UV dose for 6-thioguanine and ouabain resistance, respectively.
摘要
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