Fornstedt B, Rosengren E, Carlsson A
Neuropharmacology. 1986 Apr;25(4):451-4. doi: 10.1016/0028-3908(86)90242-x.
The 5-S-cysteinyl derivatives of dopamine, dopa (3,4-dihydroxyphenylalanine) and dopac (3,4-dihydroxyphenylacetic acid) were synthesized and used as reference compounds in high performance liquid chromatography analyses of extracts from various brain regions of eight mammalian species. All three metabolites were detected in the brains of all the species studied. The regional distribution of the metabolites was similar to that of dopamine; the metabolite concentrations ranged from less than 0.1 percent to more than 1 percent of the dopamine level, the highest ratios generally being found in substantia nigra. It is suggested that the 5-S-cysteinyl catechol metabolites have been formed after autoxidation of catechols to quinones and subsequent coupling to glutathione. The adduct thus formed is finally split by peptidases to yield the 5-S-cysteinyl derivatives.
合成了多巴胺、多巴（3,4-二羟基苯丙氨酸）和多巴胺酸（3,4-二羟基苯乙酸）的5-S-半胱氨酰衍生物，并将其用作高效液相色谱分析来自八个哺乳动物物种不同脑区提取物的参考化合物。在所研究的所有物种的大脑中均检测到了这三种代谢物。这些代谢物的区域分布与多巴胺相似；代谢物浓度范围为多巴胺水平的不到0.1%至超过1%，最高比例通常出现在黑质中。有人提出，5-S-半胱氨酰儿茶酚代谢物是在儿茶酚自氧化为醌并随后与谷胱甘肽偶联后形成的。由此形成的加合物最终被肽酶裂解，产生5-S-半胱氨酰衍生物。
