Fornstedt B, Carlsson A
Department of Pharmacology, University of Göteborg, Sweden.
J Neural Transm. 1989;76(2):155-61. doi: 10.1007/BF01578755.
Reserpine administration (5 mg/kg, i.p.) to guinea pigs resulted in marked and long lasting dopamine (DA) depletion and a rapid, short lasting, increase of 3,4-dihydroxyphenylacetic acid (DOPAC) in the striatum. A marked and sustained increase of the level of 5-S-cysteinyl-dopamine, which is an adduct presumably formed following autoxidation of DA, started 3-4 h following the DA and DOPAC changes. Only small changes in the levels of the 5-S-cysteinyl adducts of DOPAC and 3,4-dihydroxyphenylalanine (DOPA) were found.
给豚鼠腹腔注射利血平（5毫克/千克）导致纹状体中多巴胺（DA）显著且持久地耗竭，以及3,4-二羟基苯乙酸（DOPAC）迅速但短暂地增加。5-S-半胱氨酰多巴胺水平显著且持续升高，这是一种可能在DA自氧化后形成的加合物，在DA和DOPAC变化后3 - 4小时开始出现。仅发现DOPAC和3,4-二羟基苯丙氨酸（DOPA）的5-S-半胱氨酰加合物水平有微小变化。
