Wang Min, Wang Jing, Jiang Honggang
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P.R. China.
Teaching-research Office of General Practice, Hangzhou Medical College, Hangzhou, Zhejiang 310000, P.R. China.
Oncol Lett. 2019 Mar;17(3):3227-3232. doi: 10.3892/ol.2019.9957. Epub 2019 Jan 22.
Diagnostic value of apolipoprotein C-I (ApoC-I), transthyretin (TTR) and ApoC-III in gastric cancer were evaluated. Retrospective analysis methods were used to collect 60 patients with gastric cancer first diagnosed in The First Affiliated Hospital of Jiaxing University. There were 60 patients with chronic atrophic gastritis in the benign lesion group and 60 healthy individuals in the control group. The expression levels of serum ApoC-I, TTR and ApoC-III was detected by enzyme-linked immunosorbent assay. Differences existed in the expression levels of ApoC-I, TTR and ApoC-III in the gastric cancer group, benign lesion group and control group (P<0.001), with the expression levels of ApoC-I, TTR and ApoC-III in the gastric cancer group being lower than that of the benign lesion group (P<0.05), and the expression levels of ApoC-I, TTR and ApoC-III in the benign lesion group being lower than that of the control group (P<0.05). The expression levels of ApoC-I, TTR and ApoC-III in the gastric cancer group were to a certain degree correlated with the clinical stage, lymph node metastasis and differentiation of patients in the gastric cancer group (P<0.05). The specificity and negative predictive value of combined detection were proven to be higher than the separate detection of the three factors (P<0.05). The detection of serum ApoC-I, TTR and ApoC-III was of great significance in the diagnosis of gastric cancer and the estimation of its severity. The method of combined detection is worth a further in-depth study as it could improve the specificity of diagnosis and have a higher negative predictive value.
评估载脂蛋白C-I（ApoC-I）、转甲状腺素蛋白（TTR）和载脂蛋白C-III在胃癌中的诊断价值。采用回顾性分析方法，收集嘉兴学院附属第一医院首次诊断的60例胃癌患者。良性病变组有60例慢性萎缩性胃炎患者，对照组有60例健康个体。采用酶联免疫吸附测定法检测血清ApoC-I、TTR和ApoC-III的表达水平。胃癌组、良性病变组和对照组中ApoC-I、TTR和ApoC-III的表达水平存在差异（P<0.001），胃癌组中ApoC-I、TTR和ApoC-III的表达水平低于良性病变组（P<0.05），良性病变组中ApoC-I、TTR和ApoC-III的表达水平低于对照组（P<0.05）。胃癌组中ApoC-I、TTR和ApoC-III的表达水平与胃癌患者的临床分期、淋巴结转移及分化程度在一定程度上相关（P<0.05）。联合检测的特异性和阴性预测值被证明高于三种因子单独检测（P<0.05）。血清ApoC-I、TTR和ApoC-III的检测对胃癌的诊断及其严重程度的评估具有重要意义。联合检测方法值得进一步深入研究，因为它可以提高诊断的特异性并具有更高的阴性预测值。
