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滥用泻药导致杵状指:病例报告及文献综述

Nail clubbing in laxative abuse: case report and review of the literature.

作者信息

Charlton Olivia A, Dickison Philippa, Smith Saxon D, Roger Simon D

机构信息

1Department of Dermatology, Royal North Shore Hospital, Sydney, 0419125257 Australia.

The Dermatology and Skin Cancer Centre, Gosford, Australia.

出版信息

J Eat Disord. 2019 Mar 5;7:6. doi: 10.1186/s40337-019-0236-4. eCollection 2019.

DOI:10.1186/s40337-019-0236-4
PMID:30867908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6399833/
Abstract

BACKGROUND

The link between clubbing and laxative abuse has been reported several times in the literature, in all cases in young females. The nature of this relationship is not understood.

CASE

A young female, with no history of hepatic, pulmonary or malignant disease was found to have nail clubbing in the context of laxative abuse. A literature review revealed several similar cases.

CONCLUSION

Laxative abuse is an important consideration in the assessment of clubbing in populations at risk of eating disorders, to prevent over-investigation and facilitate management of the eating disorder itself. This case highlights a new clinical presentation of an eating disorder.

CASE

A 36-year-old woman was being reviewed by a renal specialist for renal impairment and electrolyte disturbances, in the context of a background of multiple renal calculi 4 years prior, hypokalaemia and hypercalcaemia. The attending nephrologist brought attention to her nails, which demonstrated clubbing. She stated that she had had clubbing for 10 years, and that it was of gradual onset and not associated with any pain. There was no history of hepatic, cardoipulmonary or malignant disease.

摘要

背景

文献中多次报道杵状指与滥用泻药之间的关联,所有病例均为年轻女性。这种关系的本质尚不清楚。

病例

一名无肝脏、肺部或恶性疾病史的年轻女性,在滥用泻药的情况下被发现有杵状指。文献回顾发现了几例类似病例。

结论

在评估有饮食失调风险人群的杵状指时,滥用泻药是一个重要的考虑因素,以避免过度检查并促进饮食失调本身的管理。该病例突出了饮食失调的一种新临床表现。

病例

一名36岁女性因肾功能损害和电解质紊乱接受肾脏专科医生复查,其背景是4年前有多发肾结石、低钾血症和高钙血症。主治肾病专家注意到她的指甲有杵状指。她说自己有杵状指已10年,起病缓慢,无任何疼痛。无肝脏、心肺或恶性疾病史。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac60/6399833/dda2f09cdc67/40337_2019_236_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac60/6399833/dda2f09cdc67/40337_2019_236_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac60/6399833/dda2f09cdc67/40337_2019_236_Fig1_HTML.jpg

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Clubbed Digits Presumably Caused by Lubiprostone.杵状指可能由鲁比前列酮引起。
Intern Med. 2021;60(15):2499-2502. doi: 10.2169/internalmedicine.6104-20. Epub 2021 Aug 1.

本文引用的文献

1
Anorexia nervosa and senna misuse: nephrocalcinosis, digital clubbing and hypertrophic osteoarthropathy.神经性厌食症与番泻叶滥用:肾钙质沉着症、杵状指及肥大性骨关节病。
Med J Aust. 2008 Sep 15;189(6):348. doi: 10.5694/j.1326-5377.2008.tb02064.x.
2
Anorexia nervosa and senna misuse: nephrocalcinosis, digital clubbing and hypertrophic osteoarthropathy.神经性厌食症与番泻叶滥用:肾钙质沉着症、杵状指和肥大性骨关节病。
Med J Aust. 2008 Jan 21;188(2):121-2. doi: 10.5694/j.1326-5377.2008.tb01540.x.
3
A rare cause of finger clubbing in a life-long nonsmoker.
终身不吸烟者出现杵状指的罕见病因。
Br J Clin Pharmacol. 2007 Feb;63(2):252. doi: 10.1111/j.1365-2125.2006.02750.x.
4
Clubbing: an update on diagnosis, differential diagnosis, pathophysiology, and clinical relevance.杵状指:诊断、鉴别诊断、病理生理学及临床相关性的最新进展
J Am Acad Dermatol. 2005 Jun;52(6):1020-8. doi: 10.1016/j.jaad.2005.01.006.
5
Finger clubbing and aspartylglucosamine excretion in a laxative-abusing patient.一名滥用泻药患者的杵状指和天冬氨酰葡糖胺排泄情况
Postgrad Med J. 1980 Dec;56(662):862-4. doi: 10.1136/pgmj.56.662.862.
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Finger clubbing associated with laxative abuse.
South Med J. 1983 Aug;76(8):1071-2. doi: 10.1097/00007611-198308000-00044.
7
Anthraquinone-induced clubbing associated with laxative abuse.蒽醌诱导的杵状指与滥用泻药有关。
Ir J Med Sci. 1983 Jun;152(6):246-7. doi: 10.1007/BF02954725.
8
Hypertrophic osteoarthropathy and purgative abuse.肥厚性骨关节病与滥用泻药
Br Med J (Clin Res Ed). 1981 Jun 6;282(6279):1836. doi: 10.1136/bmj.282.6279.1836.
9
Purgative abuse associated with reversible cachexia, hypogammaglobulinaemia, and finger clubbing.泻药滥用与可逆性恶病质、低丙种球蛋白血症和杵状指有关。
Lancet. 1981 Apr 25;1(8226):919-20. doi: 10.1016/s0140-6736(81)91616-0.
10
Reversible finger clubbing in a case of purgative abuse.一例滥用泻药病例中的可逆性杵状指
Gastroenterology. 1975 Apr;68(4 Pt 1):790-4.