Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Curr Med Sci. 2019 Feb;39(1):134-137. doi: 10.1007/s11596-019-2011-9. Epub 2019 Mar 13.
Aneurysmal fibrous histiocytoma is often clinically misdiagnosed. In this study, we put forward an insight on how to help diagnose this disease clinically. A retrospective chart review was performed on all patients diagnosed with aneurysmal fibrous histiocytoma from 2007 to 2017 in the Department of Dermatology, Union Hospital, China, and all clinical data were collected from the hospital archives. From a total of 418 patients diagnosed with cutaneous fibrous histiocytoma, only 30 patients were confirmed to have aneurysmal fibrous histiocytoma out of which only 2 patients were clinically diagnosed with aneurysmal fibrous histiocytoma. The remaining 28 patients were diagnosed with various types of vascular tumors although pathology classified them as having aneurysmal fibrous histiocytoma. Among the 30 patients, 9 were male and 21 were female. There were following age groups: 13-19 (mean 16, n=4), 20-29 (mean 26.25, n=8), 30-39 (mean 33, n=7), 40-49 (mean 44, n=4), 50-59 (mean 56.75, n=4), 60 and above (mean 61, n=3). Tumors were present on the head, neck, back, waist, hips and upper and lower extremities. After complete excision, there was no recurrence and no complications. Histologically, lesions showed the typical pseudoangiomatoid spaces without endothelial lining and infiltration of fibrohistiocytes in hemosiderotic pigmentation. It was suggested that although the prognosis of aneurysmal fibrous histiocytoma is good, accurate diagnosis is paramount to avoid clinical misdiagnosis and subsequent complications.
动脉瘤性纤维组织细胞瘤常被临床误诊。本研究提出了一种如何帮助临床诊断该疾病的见解。回顾性分析 2007 年至 2017 年在中国协和医院皮肤科诊断为动脉瘤性纤维组织细胞瘤的所有患者，并从医院档案中收集所有临床资料。在总共诊断为皮肤纤维组织细胞瘤的 418 例患者中，仅有 30 例被确认为动脉瘤性纤维组织细胞瘤，其中只有 2 例被临床诊断为动脉瘤性纤维组织细胞瘤。其余 28 例患者被诊断为各种类型的血管肿瘤，尽管病理分类为动脉瘤性纤维组织细胞瘤。在 30 例患者中，男性 9 例，女性 21 例。年龄组为：13-19 岁（平均 16 岁，n=4），20-29 岁（平均 26.25 岁，n=8），30-39 岁（平均 33 岁，n=7），40-49 岁（平均 44 岁，n=4），50-59 岁（平均 56.75 岁，n=4），60 岁及以上（平均 61 岁，n=3）。肿瘤位于头、颈、背、腰、臀部及上下肢。完全切除后无复发，无并发症。组织学上，病变表现为典型的假性血管瘤样空间，无内皮衬里，纤维组织细胞浸润含铁血黄素沉着。提示虽然动脉瘤性纤维组织细胞瘤的预后良好，但准确诊断至关重要，可避免临床误诊和随后的并发症。
