Fatima Nazish, Mohiuddin Sidra, Hosein Salim, Mervyn Mervyn
Ziauddin College of Dentistry, Ziauddin University, Karachi, Pakistan.
General Surgery, Ochsner Clinic Foundation, Jefferson, LA, USA.
J Ayub Med Coll Abbottabad. 2019 Jan-Mar;31(1):16-20.
This study was conducted to determine the age, gender and pattern of associated chewing habits among cases of oral squamous cell carcinoma (OSCC) presenting with, (OSMFCa) and without, (Ca-OSMF) pre-existing clinical oral submucous fibrosis in Karachi, Pakistan.
A cross sectional, multi centric study of (n=1009) cases with histologically confirmed oral squamous cell carcinoma seen at both public, private tertiary care hospitals and clinics over a period of eight years. A non-probability convenience sampling was used for selection of cases. Of these n=472 cases were reported as malignant transformation of clinical OSMF into OSCC: (OSMFCa) and n=537 were of OSCC without clinical evidence of OSMF: (Ca-OSMF). Qualitative analysis for gender and chewing patterns as well as chi square was performed for association. Age comparison between the OSMFCa and Ca-OSMF groups were performed by independent t test..
A total of n=1009 cases presenting with OSCC were examined. Of these 46.78% (n=472) cases were reported as OSMFCa and 53.22% (n=537) as Ca-OSMF. The comparison of age differences at presentation of OSMFCa and Ca- OSMF cases by independent t test was statistically significant (p<0.049). Both gender and chewing habits showed significant association with OSMFCa and Ca-OSMF.
Common to both affected groups was consumption of betel quid, chewing tobacco and variants with males tending to move on to more complex combinations. An overall male trend was noted in OSCC, particularly in Ca- OSMF. However, proportion of females with OSMFCa was significantly higher than males. A significantly younger female affectation in this group has significant potential socio-economic consequences.
本研究旨在确定在巴基斯坦卡拉奇患有口腔黏膜下纤维化（OSMFCa）和未患有（Ca - OSMF）口腔黏膜下纤维化的口腔鳞状细胞癌（OSCC）病例中的年龄、性别及相关咀嚼习惯模式。
一项横断面、多中心研究，对在公立、私立三级护理医院及诊所八年期间确诊的（n = 1009）例组织学确诊的口腔鳞状细胞癌病例进行研究。采用非概率便利抽样法选取病例。其中，n = 472例报告为临床OSMF恶变为OSCC：（OSMFCa），n = 537例为无OSMF临床证据的OSCC：（Ca - OSMF）。对性别和咀嚼模式进行定性分析，并进行卡方检验以分析关联性。通过独立t检验对OSMFCa组和Ca - OSMF组的年龄进行比较。
共检查了n = 1009例OSCC病例。其中46.78%（n = 472）例报告为OSMFCa，53.22%（n = 537）例为Ca - OSMF。通过独立t检验比较OSMFCa和Ca - OSMF病例就诊时的年龄差异具有统计学意义（p < 0.049）。性别和咀嚼习惯与OSMFCa和Ca - OSMF均显示出显著关联。
两个受影响组的共同之处在于食用槟榔、咀嚼烟草及其变体，男性倾向于转向更复杂的组合。在OSCC中总体呈现男性趋势，尤其是在Ca - OSMF中。然而，OSMFCa中女性的比例显著高于男性。该组中受影响的女性明显更年轻，具有重大的潜在社会经济后果。
