Drapier-Faure E
Rev Fr Gynecol Obstet. 1986 Apr;81(4):179-84.
Current, improved understanding of the physiopathology of polycystic ovary syndrome offers the possibility of more suitable treatment. Formerly, objectives differed for a given patient: re-establish regular cycles using progestogens or estroprogestogens, reduce hirsutism with antiandrogens, trigger ovulation. Clomid is the inducer of choice, but setbacks occur. Injectable gonadotropins were, in principle, a contraindication due to the high incidence of excess stimulation and multiple pregnancy. The introduction of purified FSH offers another method of stimulation. Severe excess stimulation is eliminated with a suitable protocol involving administration of small doses. This offers hope, but as yet no large-scale trial has been published.
目前，对多囊卵巢综合征生理病理学的深入了解为更合适的治疗提供了可能。以前，针对特定患者的目标各不相同：使用孕激素或雌孕激素恢复规律月经周期，用抗雄激素减少多毛症，诱导排卵。克罗米芬是首选的诱导剂，但也会出现问题。原则上，由于过度刺激和多胎妊娠的发生率较高，注射用促性腺激素是一种禁忌。纯化促卵泡激素的引入提供了另一种刺激方法。通过采用涉及小剂量给药的合适方案，可以消除严重的过度刺激。这带来了希望，但尚未发表大规模试验。
