用多聚甲醛和 H 对喹啉进行还原 N-甲基化反应，可持续合成 N-甲基四氢喹啉。
Reductive N-methylation of quinolines with paraformaldehyde and H for sustainable synthesis of N-methyl tetrahydroquinolines.
机构信息
State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000, China.
出版信息
Chem Commun (Camb). 2019 Apr 7;55(27):3915-3918. doi: 10.1039/c8cc10309g. Epub 2019 Mar 14.
A new and straightforward method was developed for the synthesis of N-methyl-1,2,3,4-tetrahydroquinolines by one-pot reductive N-methylation of quinolines with paraformaldehyde and H over Pd/C catalyst. A series of functional MTHQs, including (±)-galipinine and (±)-angustrureine were successfully synthesized in good to excellent yields by applying this simple catalyst system.
开发了一种新的、简便的方法，通过一锅法将对苯二甲醛和 H 还原 Pd/C 催化剂与喹啉进行还原 N-甲基化，合成 N-甲基-1,2,3,4-四氢喹啉。通过应用这种简单的催化剂体系，成功地以良好到优异的收率合成了一系列功能 MTHQs，包括（±）-高利定碱和（±）-angustrureine。
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