State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000, China.
Chem Commun (Camb). 2019 Apr 7;55(27):3915-3918. doi: 10.1039/c8cc10309g. Epub 2019 Mar 14.
A new and straightforward method was developed for the synthesis of N-methyl-1,2,3,4-tetrahydroquinolines by one-pot reductive N-methylation of quinolines with paraformaldehyde and H over Pd/C catalyst. A series of functional MTHQs, including (±)-galipinine and (±)-angustrureine were successfully synthesized in good to excellent yields by applying this simple catalyst system.
开发了一种新的、简便的方法，通过一锅法将对苯二甲醛和 H 还原 Pd/C 催化剂与喹啉进行还原 N-甲基化，合成 N-甲基-1,2,3,4-四氢喹啉。通过应用这种简单的催化剂体系，成功地以良好到优异的收率合成了一系列功能 MTHQs，包括（±）-高利定碱和（±）-angustrureine。
