铁(ii)催化的重氮化合物与苄位 C-H 键的烯基化反应。
Fe(ii)-Catalyzed alkenylation of benzylic C-H bonds with diazo compounds.
机构信息
Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
出版信息
Chem Commun (Camb). 2019 Apr 2;55(28):4047-4050. doi: 10.1039/c9cc01060b.
We report herein an alkenylation of benzylic C(sp3)-H bonds with diazo compounds via carbon cation intermediates with DDQ as the oxidant in the presence of a catalytic amount of Fe(ii). Diphenylmethane, toluene, benzyl methyl sulfide and their derivatives could be applied as substrates to afford the tetra-substituted olefin products, which may serve as useful building blocks in organic synthesis.
我们在此报告了一种通过碳正离子中间体与重氮化合物的烯丙基化反应，在 DDQ 作为氧化剂和催化量的 Fe(ii)存在下实现苄位 C(sp3)-H 键的官能化。二苯甲烷、甲苯、苄基甲基硫醚及其衍生物可用作底物，以提供四取代烯烃产物，这些产物可能在有机合成中作为有用的构建块。
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