电化学三氟甲基化/半频哪醇重排序列的烯基醇：β-CF 取代酮的合成。
Electrochemical trifluoromethylation/semipinacol rearrangement sequences of alkenyl alcohols: synthesis of β-CF-substituted ketones.
机构信息
Department of Chemistry, Soonchunhyang University, Asan 31538, Chungnam, Republic of Korea.
出版信息
Org Biomol Chem. 2019 Mar 27;17(13):3319-3323. doi: 10.1039/c9ob00373h.
PMID:30869722
Abstract
Electrochemical oxidative radical trifluoromethylation/semipinacol rearrangement sequences of alkenyl alcohols were developed in this study. This approach is environmentally benign and uses the shelf-stable Langlois reagent as a trifluoromethyl radical precursor and electrons as the oxidizing reagents. The present protocol offers a facile route to prepare β-trifluoromethylated ketone derivatives.
摘要
本研究开发了烯丙醇的电化学氧化自由基三氟甲基化/半频哪醇重排序列。该方法具有环境友好性，使用货架稳定的朗格洛伊斯试剂作为三氟甲基自由基前体，电子作为氧化剂。本方案为制备β-三氟甲基化酮衍生物提供了一种简便的途径。
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