Electrochemical Intramolecular Oxytrifluoromethylation of -Tethered Alkenyl Alcohols: Synthesis of Functionalized Morpholines.

An electrochemical intramolecular oxytrifluoromethylation of -tethered alkenyl alcohols was developed providing straightforward access to CF-containing morpholines derivatives. The method features mild reaction conditions with direct anodic oxidation of Langlois reagent as a cheap and easy to handle trifluoromethylating reagent. Variously substituted 2-(2,2,2-trifluoroethyl)morpholines were obtained in moderate to high yields under constant current electrolysis in an undivided cell.