单链尿激酶原在兔颈静脉血栓形成模型中的溶栓作用
Thrombolytic effect of single-chain pro-urokinase in a rabbit jugular vein thrombosis model.
作者信息
Matsuo O, Bando H, Okada K, Tanaka K, Tsukada M, Iga Y, Arimura H
出版信息
Thromb Res. 1986 Apr 15;42(2):187-94. doi: 10.1016/0049-3848(86)90294-x.
The thrombolytic effect of single-chain pro-urokinase (SCPU) was examined in the rabbit using a jugular vein thrombosis model. Infusion of a low dose (120,000 IU/kg) of either urokinase (UK) or SCPU did not produce any significant thrombolysis. However, UK administration at such a low dose caused 20% degradation of circulating fibrinogen. A high dose (480,000 IU/kg) caused significant thrombolysis. The degree of fibrinogenolysis was about 20% in SCPU, but about 80% in UK. The thrombolytic efficiency of SCPU was thus about 3 times larger than that of UK. Analysis of fibrinolytic parameters such as plasminogen, alpha 2-plasmin inhibitor, etc. suggested that UK caused systemic activation of the fibrinolytic system, but SCPU, locally limited activation on the fibrin surface (fibrinolysis). These results indicate that SCPU represents a highly efficient thrombolytic agent without producing fibrinogenolysis.
采用颈静脉血栓形成模型在兔身上研究了单链前尿激酶（SCPU）的溶栓作用。输注低剂量（120,000 IU/kg）的尿激酶（UK）或SCPU均未产生任何显著的溶栓效果。然而，以如此低剂量给予UK会导致循环纤维蛋白原降解20%。高剂量（480,000 IU/kg）会引起显著的溶栓作用。SCPU中的纤维蛋白原溶解程度约为20%，而UK中约为80%。因此，SCPU的溶栓效率约为UK的3倍。对纤溶参数如纤溶酶原、α2-纤溶酶抑制剂等的分析表明，UK引起纤溶系统的全身激活，而SCPU则在纤维蛋白表面局部限制激活（纤维蛋白溶解）。这些结果表明，SCPU是一种高效的溶栓剂，不会产生纤维蛋白原溶解。
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