确诊风湿热和风湿性心脏病患者的人类白细胞抗原、血型及分泌型状态

HLA, blood groups and secretor status in patients with established rheumatic fever and rheumatic heart disease.

作者信息

Jhinghan B, Mehra N K, Reddy K S, Taneja V, Vaidya M C, Bhatia M L

出版信息

Tissue Antigens. 1986 Mar;27(3):172-8. doi: 10.1111/j.1399-0039.1986.tb01517.x.

DOI:10.1111/j.1399-0039.1986.tb01517.x

Abstract

The distribution of HLA-A, -B and -DR antigens as well as blood groups and secretor status was studied in sporadic, North Indian patients of rheumatic fever and rheumatic heart disease. While HLA-Aw33 occurred with an increased frequency in the patient group (X2 = 4.01), no statistically significant differences were observed in the frequency of B-locus antigens. In the DR locus, HLA-DR3 was found to be significantly increased (50% vs 26.1%, X2 = 13.8) and DR2 significantly reduced (21.8% vs 47.0%, X2 = 15.6). Also, there was a preponderance of non-'O' blood group individuals in the patient group as compared to controls. The DR3 association was significant only in those patients of RHD who did not have any previous history of rheumatic fever. These results indicate that susceptibility to rheumatic heart disease is HLA-class II mediated, with HLA-DR3 influencing susceptibility and DR2 conferring protection.

摘要

对散发性北印度风湿热和风湿性心脏病患者的HLA - A、- B和 - DR抗原分布以及血型和分泌状态进行了研究。虽然患者组中HLA - Aw33出现频率增加（X2 = 4.01），但B位点抗原频率未观察到统计学显著差异。在DR位点，发现HLA - DR3显著增加（50%对26.1%，X2 = 13.8），DR2显著降低（21.8%对47.0%，X2 = 15.6）。此外，与对照组相比，患者组中非“O”血型个体占优势。DR3关联仅在那些无风湿热既往史的风湿性心脏病患者中显著。这些结果表明，风湿性心脏病易感性是由HLA - II类介导的，HLA - DR3影响易感性，DR2提供保护。