Khanna A K, Buskirk D R, Williams R C, Gibofsky A, Crow M K, Menon A, Fotino M, Reid H M, Poon-King T, Rubinstein P
Rockefeller University, New York 10021.
J Clin Invest. 1989 May;83(5):1710-6. doi: 10.1172/JCI114071.
Numerous investigators have suspected that there is a genetic predisposition to rheumatic fever (RF). In this context we have recently produced a series of monoclonal antibodies directed against B cells obtained from RF patients one of which, labeled D8/17, identifies a B cell antigen present in 100% of all RF patients studied. While the highest percentage of positive cells were exhibited by RF probands (33.5% +/- SE), the percentage of cells in unaffected siblings and parents was 14.6 and 13%, respectively. The percentage of positive cells in APSGN probands, unaffected siblings, and parents was 2.96, 3.86, and 2.8%, respectively. A low level of B cells (5-7%) bearing the D8/17 marker was seen in control patients. The segregation pattern of the phenotypes defined by the percentage of D8/17 positive cells within HLA-typed RF families are consistent with an autosomal recessive mode of inheritance not associated with the human MHC system. We postulate that these phenotypes indicate the presence of at least one necessary genetic factor for susceptibility to RF.
众多研究人员怀疑风湿热（RF）存在遗传易感性。在此背景下，我们最近制备了一系列针对从RF患者获取的B细胞的单克隆抗体，其中一种标记为D8/17的抗体可识别所有研究的RF患者中100%存在的一种B细胞抗原。虽然RF先证者显示出最高比例的阳性细胞（33.5%±标准误），但未受影响的同胞和父母中的细胞比例分别为14.6%和13%。急性链球菌感染后肾小球肾炎（APSGN）先证者、未受影响的同胞和父母中的阳性细胞比例分别为2.96%、3.86%和2.8%。在对照患者中可见低水平（5 - 7%）携带D8/17标记的B细胞。在HLA分型的RF家族中，由D8/17阳性细胞百分比定义的表型分离模式与一种不与人MHC系统相关的常染色体隐性遗传模式一致。我们推测这些表型表明存在至少一种对RF易感性的必要遗传因素。
