Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York; and the Department of Neurological Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Obstet Gynecol. 2019 Apr;133(4):712-719. doi: 10.1097/AOG.0000000000003099.
To analyze risk factors, temporality, and outcomes for women readmitted postpartum for a hypertensive indication who did not have a hypertensive diagnosis during their delivery hospitalization.
The Healthcare Cost and Utilization Project's Nationwide Readmissions Database for 2010-2014 was used to evaluate risk for postpartum readmission for preeclampsia and hypertension within 60 days of discharge from a delivery hospitalization among women without these diagnoses during delivery in this cohort study. Obstetric, medical, demographic, and hospital factors associated with postpartum readmission were analyzed. Both unadjusted and adjusted analyses were performed. Risk was characterized as unadjusted and adjusted risk ratio with 95% CI. As a secondary outcome, risk for severe maternal morbidity during readmissions was also evaluated comparing women with and without hypertensive diagnoses during their delivery hospitalization.
Among delivery hospitalizations without a hypertensive diagnosis at delivery, absolute rates of readmission within 60 days for a hypertensive indication were low, with one readmission occurring per 687 deliveries for all women. The rate rose to 1 in 498 among women 35-39 years of age, 1 in 337 for women 40-54, 1 in 601 for women with Medicaid, 1 in 506 for women with Medicare, 1 in 497 with cesarean delivery, 1 in 600 with postpartum hemorrhage, 1 in 455 and 1 in 378 for gestational and pregestational diabetes, respectively, 1 in 428 for asthma, 1 in 225 for chronic kidney disease, and 1 in 214 for lupus. For the secondary outcome, risk for severe maternal morbidity was higher for women without a hypertensive indication during their delivery compared with women with a diagnosis (12.1% vs 6.9%, P<.01).
Risk for hypertensive postpartum readmissions for women without delivery-hospitalization preeclampsia or hypertension is low. Future comparative effectiveness and clinical research is indicated to determine whether earlier postpartum identification of elevated blood pressure followed by increased surveillance and counseling may further reduce risk.
分析产后因高血压指征再次入院且分娩住院期间无高血压诊断的女性的危险因素、时间和结局。
本队列研究使用 2010-2014 年全美再入院数据库(Healthcare Cost and Utilization Project's Nationwide Readmissions Database),评估了在分娩住院期间无产前子痫和高血压诊断的女性在出院后 60 天内因高血压再次入院的风险。分析了与产后再入院相关的产科、医疗、人口统计学和医院因素。进行了未经调整和调整后的分析。风险特征为未经调整和调整后的风险比及其 95%置信区间。作为次要结局,还比较了分娩住院期间有或无高血压诊断的女性在再入院期间发生严重产妇发病率的风险。
在分娩住院期间无高血压诊断的女性中,60 天内因高血压指征再次入院的绝对比率较低,所有女性的再入院率为每 687 例分娩一例。对于年龄在 35-39 岁的女性,该比率上升至每 498 例一例;对于年龄在 40-54 岁的女性,该比率上升至每 337 例一例;对于接受医疗补助的女性,该比率上升至每 601 例一例;对于接受医疗保险的女性,该比率上升至每 506 例一例;对于剖宫产的女性,该比率上升至每 497 例一例;对于产后出血的女性,该比率上升至每 600 例一例;对于妊娠糖尿病和妊娠期糖尿病的女性,该比率分别上升至每 455 例一例和每 378 例一例;对于哮喘的女性,该比率上升至每 428 例一例;对于慢性肾脏病的女性,该比率上升至每 225 例一例;对于狼疮的女性,该比率上升至每 214 例一例。对于次要结局,与分娩住院期间有高血压诊断的女性相比,无高血压指征的女性发生严重产妇发病率的风险更高(12.1%比 6.9%,P<.01)。
对于分娩住院期间无产前子痫或高血压的女性,产后高血压再次入院的风险较低。需要进一步开展比较有效性和临床研究,以确定是否可以通过更早地识别产后血压升高并增加监测和咨询来进一步降低风险。