运动对胰岛素热效应的增强作用：瘦、肥胖及非胰岛素依赖型糖尿病男性之间的差异。

Potentiation of the thermic effect of insulin by exercise: differences between lean, obese, and noninsulin-dependent diabetic men.

作者信息

Devlin J T, Horton E S

出版信息

Am J Clin Nutr. 1986 Jun;43(6):884-90. doi: 10.1093/ajcn/43.6.884.

DOI:10.1093/ajcn/43.6.884

Abstract

We studied the effects of prior high-intensity cycle exercise (85% VO2 max) on total energy expenditure (EE) and the thermic effect of insulin (TEI) in normal controls and in obese insulin-resistant and noninsulin-dependent diabetic (NIDDM) subjects. Normal controls, but not obese or NIDDM subjects, showed a significant increase (3-7%) in total EE 12-16 h after exercise (p less than 0.05). Prior exercise increased lipid and decreased glucose oxidation in all groups. During low-dose insulin infusion (40 mU X M2 X min), prior exercise potentiated TEI in control and NIDDM subjects (p less than 0.05), whereas obese subjects showed no response. During high-dose insulin infusion (400 mU X M2 X min), TEI was similar in NIDDM and control subjects but was significantly less in the obese group. In this study, we found a positive correlation between TEI and insulin-stimulated rates of glucose disposal (r = 0.91, p less than 0.001). The predicted cost of glucose storage accounted for 42% of TEI.

摘要

我们研究了先前的高强度自行车运动（85%最大摄氧量）对正常对照组、肥胖胰岛素抵抗和非胰岛素依赖型糖尿病（NIDDM）受试者的总能量消耗（EE）和胰岛素热效应（TEI）的影响。正常对照组在运动后12 - 16小时总EE显著增加（3 - 7%）（p < 0.05），而肥胖或NIDDM受试者未出现此现象。先前的运动使所有组的脂质氧化增加，葡萄糖氧化减少。在低剂量胰岛素输注期间（40 mU×M2×min），先前的运动增强了对照组和NIDDM受试者的TEI（p < 0.05），而肥胖受试者无反应。在高剂量胰岛素输注期间（400 mU×M2×min），NIDDM和对照组受试者的TEI相似，但肥胖组显著较低。在本研究中，我们发现TEI与胰岛素刺激的葡萄糖处置率之间呈正相关（r = 0.91，p < 0.001）。葡萄糖储存的预测成本占TEI的42%。