Sakakura M, Saito Y, Yoshioka M, Takebe K, Yamashita I
Tohoku J Exp Med. 1978 Jul;125(3):281-5. doi: 10.1620/tjem.125.281.
It is well known that hypothalamic corticotropin releasing factor (CRF) activity shows a marked circadian rhythm with the peak around 16 o'clock and the minimal level around 8 o'clock, followed by almost parallel changes of plasma corticosterone. But the circadian variations of CRF activity at short intervals (22 or 23 min) around 16 o'clock has not been obvious. In this experiment, we demonstrated fluctuated changes of CRF content in the non-stressed rat hypothalamus with 22 or 23 min intervals around the peak at a quarter past 16 o'clock.
众所周知，下丘脑促肾上腺皮质激素释放因子（CRF）的活性呈现出明显的昼夜节律，峰值约在16点左右，最低水平约在8点左右，随后血浆皮质酮也几乎同步变化。但在16点左右短时间间隔（22或23分钟）内CRF活性的昼夜变化并不明显。在本实验中，我们证明了在16点15分左右的峰值附近，非应激大鼠下丘脑CRF含量以22或23分钟的间隔呈现波动变化。
