Department of Donor Medicine Research - Donor Studies, Sanquin Research, Amsterdam, The Netherlands.
Department of Internal Medicine, VU University Medical Centre, Amsterdam, The Netherlands.
Heart. 2019 Aug;105(16):1260-1265. doi: 10.1136/heartjnl-2018-314138. Epub 2019 Mar 14.
To investigate whether regular blood donation decreases cardiovascular risk.
All 159 934 Dutch whole-blood donors with an active donation career of at least 10 years were categorised into sex-specific donation tertiles based on the number of donations during this 10-year qualification period. Cardiovascular endpoints were based on hospital discharge diagnoses and death certificates from Dutch Hospital Data and Statistics Netherlands and occurring after the 10-year qualification period. Cox regression was used to estimate the age-adjusted and starting year-adjusted hazard rate ratio (HRR).
Female high-frequency blood donors had a reduced cardiovascular morbidity (HRR=0.91, 95% CI 0.85 to 0.98) compared with low-frequency blood donors. No effect was observed in men (HRR=1.00, 95% CI 0.95 to 1.05). To rule out a residual healthy donor effect (HDE), additional sensitivity analyses using a 5-year qualification period were conducted. The results supported the absence of a residual HDE.
This study showed a protective effect of long-term, high-frequency blood donation against cardiovascular disease. This effect was only observed in women and not in men.
探讨定期献血是否降低心血管风险。
根据在 10 年资格期内的献血次数，将所有至少有 10 年活跃献血经历的 159934 名荷兰全血献血者分为按性别划分的献血三分位组。心血管终点基于荷兰医院数据和荷兰统计局的住院诊断和死亡证明，并发生在 10 年资格期之后。使用 Cox 回归估计年龄调整和起始年份调整的危险比（HRR）。
与低频献血者相比，女性高频献血者的心血管发病率降低（HRR=0.91，95%CI 0.85 至 0.98）。男性未观察到效果（HRR=1.00，95%CI 0.95 至 1.05）。为排除残余健康献血者效应（HDE），使用 5 年资格期进行了额外的敏感性分析。结果支持不存在残余 HDE。
本研究表明长期、高频献血对心血管疾病具有保护作用。这种作用仅在女性中观察到，而在男性中未观察到。
