Myers D J, Bigby B G, Boushey H A
Am Rev Respir Dis. 1986 Jun;133(6):1150-3. doi: 10.1164/arrd.1986.133.6.1150.
To determine whether the inhibitory effect of cromolyn on sulfur dioxide-induced bronchoconstriction is dose dependent, we compared the effects of treatment with 200 mg of cromolyn, with 20 mg of cromolyn, and with placebo on the rise in specific airway resistance provoked by inhalation of serially increasing concentrations of sulfur dioxide (0.25 to 8.0 ppm) in 10 asthmatic subjects. The geometric mean concentration of sulfur dioxide needed to cause an increase in SRaw of 8 L X cm H2O/L/s was significantly greater after 200 mg of cromolyn (1.98 ppm) than after 20 mg of cromolyn (0.94 ppm), which was in turn significantly greater than after placebo (0.35 ppm). We then examined whether the greater protection afforded by 200 mg of cromolyn was due to direct inhibition of smooth muscle contraction. We measured the bronchomotor response to the inhalation of serially increasing concentrations of methacholine aerosol (0.06 to 2.0 mg/ml) in 7 asthmatic subjects. Again, each subject was treated on 3 separate days with 200 mg of cromolyn, with 20 mg of cromolyn, and with placebo. We found that methacholine responsiveness was not decreased by either dose of cromolyn. We conclude that cromolyn inhibits sulfur dioxide-induced bronchoconstriction in a dose-dependent manner and that it does not directly inhibit smooth muscle responsiveness.
为了确定色甘酸钠对二氧化硫诱发的支气管收缩的抑制作用是否呈剂量依赖性，我们比较了200毫克色甘酸钠、20毫克色甘酸钠及安慰剂对10名哮喘患者吸入浓度逐渐增加的二氧化硫（0.25至8.0 ppm）所引起的气道比阻力升高的治疗效果。吸入二氧化硫后，引起气道比阻力升高8 L·cm H₂O/L/s所需的二氧化硫几何平均浓度，在使用200毫克色甘酸钠后（1.98 ppm）显著高于使用20毫克色甘酸钠后（0.94 ppm），而使用20毫克色甘酸钠后的该浓度又显著高于使用安慰剂后（0.35 ppm）。然后我们研究了200毫克色甘酸钠提供的更强保护作用是否源于对平滑肌收缩的直接抑制。我们测量了7名哮喘患者吸入浓度逐渐增加的乙酰甲胆碱气雾剂（0.06至2.0毫克/毫升）后的支气管运动反应。同样，每位受试者在3个不同的日子里分别接受200毫克色甘酸钠、20毫克色甘酸钠及安慰剂治疗。我们发现，两种剂量的色甘酸钠均未降低乙酰甲胆碱反应性。我们得出结论，色甘酸钠以剂量依赖性方式抑制二氧化硫诱发的支气管收缩，且它并不直接抑制平滑肌反应性。
