站立马匹中使用阿米卡星和青霉素联合进行肢体局部灌注的药代动力学
Pharmacokinetics of regional limb perfusion using a combination of amikacin and penicillin in standing horses.
作者信息
Dahan Roee, Oreff Gil L, Tatz Amos J, Raz Tal, Britzi Malka, Kelmer Gal
机构信息
Department of Large Animal Medicine and Surgery, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, the Hebrew University of Jerusalem, Israel (Dahan, Oreff, Tatz, Raz, Kelmer); Kimron Veterinary Institute, National Residue Control Laboratory, Bet Dagan, Israel (Britzi).
出版信息
Can Vet J. 2019 Mar;60(3):294-299.
The objectives of this study were to evaluate the compatibility and the pharmacokinetic properties of combined amikacin and penicillin administration by intravenous regional limb perfusion (IVRLP) in horses. A tourniquet was applied proximal to the carpus of 7 clinically healthy adult horses and 2 g of amikacin and 10 × 10 IU of penicillin (100 mL total volume) were sequentially injected into the cephalic vein just distal to the tourniquet. Synovial samples were collected from the joint at several times after injection. All samples were analyzed for amikacin and penicillin concentration. The mean maximum concentration (C) of both amikacin and penicillin was over 10-fold the relevant minimal inhibitory concentration (MIC) for all horses and remained above those MICs for at least 24 hours. The results of this study indicate that combining amikacin with penicillin during IVRLP in normal horses delivers high therapeutic synovial concentrations of both drugs.
本研究的目的是评估在马中通过静脉区域肢体灌注（IVRLP）联合使用阿米卡星和青霉素的相容性及药代动力学特性。对7匹临床健康的成年马，在腕关节近端应用止血带，然后在止血带远端的头静脉中依次注射2 g阿米卡星和10×10 IU青霉素（总体积100 mL）。注射后在不同时间从关节采集滑膜样本。所有样本均分析阿米卡星和青霉素浓度。所有马匹中，阿米卡星和青霉素的平均最大浓度（C）均超过相关最低抑菌浓度（MIC）的10倍以上，并且至少24小时保持在这些MIC之上。本研究结果表明，在正常马进行IVRLP期间将阿米卡星与青霉素联合使用可使两种药物在滑膜中达到高治疗浓度。
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