Martínez-Riera Roser, Pérez-Mañá Clara, Papaseit Esther, Fonseca Francina, de la Torre Rafael, Pizarro Nieves, Torrens Marta, Farré Magí
Institut de Neuropsiquiatria i Addiccions, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
Department of Psychiatry and Legal Medicine and Department of Pharmacology, Therapeutics and Toxicoloy, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Spain.
Front Pharmacol. 2019 Feb 27;10:131. doi: 10.3389/fphar.2019.00131. eCollection 2019.
Soy beans contain isoflavones, including daidzein and genistein, with biological activities related to therapeutic effects in reducing osteoporosis, decreasing adverse menopausal manifestations, providing protection from cardiovascular diseases, and reducing hormone-dependent cancers and age-related cognitive-decline. Daidzein has been described as inhibiting the aldehyde-dehydrogenase-2 enzyme (ALDH2), and reducing alcohol use in clinical pilot studies. Our aim was to evaluate the possible interactions between a soy extract product and alcohol in a crossover, single blind, randomized study. Ten healthy male volunteers participated in two experimental sessions: one with a single dose of alcohol (0.5 g/kg, Vodka Absolut, Sweden), and the other with four capsules of a soy extract product (Super-Absorbable Soy Isoflavones, Life-Extension, United States) and, 2 h later, the same dose of alcohol. Results showed no differences in vital signs except a slightly higher significative reduction in diastolic blood pressure at 2, 3, 4, and 8 h after administration with alcohol alone in comparison with soy extract+alcohol. Ethanol-induced subjective and adverse effects were similar for both conditions with the exception of headache (higher at 8 h after alcohol alone). Our results demonstrate that a single dose of a soy isoflavone extract did not influence alcohol pharmacokinetics and pharmacological effects and did not induce any disulfiram-reaction symptoms. Soy extract and alcohol did not interact and can be administered safely.
大豆含有异黄酮，包括黄豆苷元和染料木黄酮，其生物活性与减轻骨质疏松症、减少更年期不良症状、预防心血管疾病、降低激素依赖性癌症以及缓解与年龄相关的认知衰退等治疗效果有关。在临床前期研究中，黄豆苷元被描述为可抑制乙醛脱氢酶2（ALDH2）并减少酒精摄入。我们的目的是在一项交叉、单盲、随机研究中评估一种大豆提取物产品与酒精之间可能的相互作用。十名健康男性志愿者参与了两个实验阶段：一个阶段是单次服用酒精（0.5 g/kg，瑞典绝对伏特加），另一个阶段是服用四粒大豆提取物产品胶囊（美国生命延长公司的超级可吸收大豆异黄酮），2小时后再服用相同剂量的酒精。结果显示，除了与大豆提取物+酒精相比，单独服用酒精后2、3、4和8小时舒张压的显著降低幅度略高外，生命体征没有差异。两种情况下，乙醇引起的主观和不良反应相似，但头痛情况除外（单独饮酒后8小时头痛更严重）。我们的结果表明，单剂量的大豆异黄酮提取物不会影响酒精的药代动力学和药理作用，也不会引发任何双硫仑样反应症状。大豆提取物和酒精不会相互作用，可以安全服用。
