辣椒素及其类似物对小鼠体温降低反应的研究。

Studies on the hypothermic response of capsaicin and its analogue in mice.

作者信息

Fujii T, Ohbuchi Y, Takahashi S, Sakurada T, Sakurada S, Ando R, Kisara K

出版信息

Arch Int Pharmacodyn Ther. 1986 Mar;280(1):165-76.

Abstract

Administration of capsaicin (CAP) and its related pungent, nonanoyl vanillylamide (NVA) produced significant dose-dependent hypothermic response in mice at an ambient temperature of 24 degrees C. CAP was approximately equieffective to NVA in producing hypothermia. After large doses, desensitization occurred to the hypothermic effects of both CAP and NVA. The hypothermia produced by CAP and NVA was prevented by a small dose of thyrotropin-releasing hormone (TRH) (0.25 nmol/animal) which by itself had little effect on body temperature. Histidyl-proline diketopiperazine, a metabolite of TRH, was without effect on the hypothermic response of CAP and NVA. The result suggests that a TRH neuronal system in the brain may explain a part of the mechanism of CAP- and NVA-induced hypothermia in mice.

摘要

在24摄氏度的环境温度下，给小鼠施用辣椒素（CAP）及其相关的辛辣物质壬酰香草酰胺（NVA）会产生显著的剂量依赖性体温降低反应。在产生体温降低方面，CAP与NVA的效果大致相当。大剂量给药后，对CAP和NVA的体温降低作用均出现了脱敏现象。小剂量的促甲状腺激素释放激素（TRH）（0.25 nmol/只动物）可预防由CAP和NVA引起的体温降低，而TRH本身对体温几乎没有影响。组氨酰 - 脯氨酸二酮哌嗪是TRH的一种代谢产物，对CAP和NVA的体温降低反应没有作用。结果表明，大脑中的TRH神经元系统可能解释了CAP和NVA诱导小鼠体温降低机制的一部分。