微波辅助合成磷原子上带有不同取代基的双（磷酰基甲基）胺和三（磷酰基甲基）胺。

Bálint Erika, Tripolszky Anna, Hegedűs László, Keglevich György

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary.

Beilstein J Org Chem. 2019 Feb 15;15:469-473. doi: 10.3762/bjoc.15.40. eCollection 2019.

A family of ,-bis(phosphinoylmethyl)amines bearing different substituents on the phosphorus atoms was synthesized by the microwave-assisted and catalyst-free Kabachnik-Fields reaction of (aminomethyl)phosphine oxides with paraformaldehyde and diphenylphosphine oxide. The three-component condensation of -bis(phosphinoylmethyl)amine, paraformaldehyde and a secondary phosphine oxide affording -tris(phosphinoylmethyl)amine derivatives was also elaborated. This method is a novel approach for the synthesis of the target products.

通过（氨甲基）氧化膦与多聚甲醛和二苯基氧化膦的微波辅助无催化剂卡巴契克-菲尔德反应，合成了一类在磷原子上带有不同取代基的α,ω-双（磷酰基甲基）胺。还详细研究了α,ω-双（磷酰基甲基）胺、多聚甲醛和仲氧化膦的三组分缩合反应，得到了α,ω-三（磷酰基甲基）胺衍生物。该方法是合成目标产物的一种新方法。