Mogard M H, Kobayashi R, Chen C F, Lee T D, Reeve J R, Shively J E, Walsh J H
Biochem Biophys Res Commun. 1986 May 14;136(3):983-8. doi: 10.1016/0006-291x(86)90429-8.
A novel nonapeptide with neurotensin-like immunoreactivity was isolated from pepsin-treated human plasma by dialysis, ion-exchange chromatography and high performance reversed-phase liquid chromatography. The amino acid sequence was determined by automated gas-phase sequence analysis as Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu. Sequence homology with human serum albumin and with the biologically active peptides neurotensin and angiotensin is demonstrated. The name proposed for this peptide is kinetensin.
通过透析、离子交换色谱和高效反相液相色谱法，从经胃蛋白酶处理的人血浆中分离出一种具有神经降压素样免疫反应性的新型九肽。通过自动气相序列分析确定其氨基酸序列为异亮氨酸-丙氨酸-精氨酸-精氨酸-组氨酸-脯氨酸-酪氨酸-苯丙氨酸-亮氨酸。证实了其与人血清白蛋白以及生物活性肽神经降压素和血管紧张素的序列同源性。为该肽提议的名称是动素。
