舒洛地特（一种类肝素糖胺聚糖）的一个组分的化学和生物学特性研究。

Studies of chemical and biologic properties of a fraction of sulodexide, a heparin-like glycosaminoglycan.

作者信息

Radhakrishnamurthy B, Sharma C, Bhandaru R R, Berenson G S, Stanzani L, Mastacchi R

出版信息

Atherosclerosis. 1986 May;60(2):141-9. doi: 10.1016/0021-9150(86)90006-7.

Abstract

The chemical composition and biologic properties of a fraction (f) of Sulodexide, a heparin-like GAG, were studied and compared with those of two sulfated GAG preparations and heparin from intestinal mucosa. f-Sulodexide and the sulfated GAG preparations were fractionated on a Dowex-1Cl- column and subsequently on an antithrombin III affinity column. Low affinity and high affinity fractions had similar chemical composition and lipoprotein lipase releasing ability, but they varied in anticoagulant activity. Low affinity fractions from f-Sulodexide had negligible anticoagulant activity while high affinity fractions had one-half the activity of mucosal heparin. When compared to heparin, both fractions had one third amount of lipoprotein lipase releasing activity. The low anticoagulant activity of f-Sulodexide suggests a suitability for long-term use as an antiatherogenic agent.

摘要

研究了类肝素糖胺聚糖舒洛地希的一个组分（f）的化学成分和生物学特性，并将其与两种硫酸化糖胺聚糖制剂以及来自肠黏膜的肝素进行比较。f-舒洛地希和硫酸化糖胺聚糖制剂先在Dowex-1Cl-柱上进行分离，随后在抗凝血酶III亲和柱上进行分离。低亲和力和高亲和力组分具有相似的化学成分和脂蛋白脂肪酶释放能力，但它们的抗凝活性有所不同。f-舒洛地希的低亲和力组分抗凝活性可忽略不计，而高亲和力组分的活性为黏膜肝素的一半。与肝素相比，两个组分的脂蛋白脂肪酶释放活性均为其三分之一。f-舒洛地希的低抗凝活性表明其适合作为抗动脉粥样硬化药物长期使用。