Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil.
Departamento de Química e Bioquímica, Laboratório de Bioensaios e Dinâmica Celular, Universidade Estadual Paulista (UNESP), Instituto de Biociências, Campus Botucatu, Botucatu, Brazil.
Physiol Behav. 2019 May 15;204:309-323. doi: 10.1016/j.physbeh.2019.03.009. Epub 2019 Mar 12.
Obesity and metabolic disorders are increasing worldwide and are associated with brain atrophy and dysfunction, which are risk factors for late-onset dementia and Alzheimer's disease. Epidemiological studies demonstrated that changes in lifestyle, including the frequent practice of physical exercise are able to prevent and treat not only obesity/metabolic disorders, but also to improve cognitive function and dementia. Several biochemical pathways and epigenetic mechanisms have been proposed to understand the beneficial effects of physical exercise on cognition. This manuscript revised central ongoing research on epigenetic mechanisms induced by exercise and the beneficial effects on obesity-associated cognitive decline, highlighting potential mechanistic mediators.
肥胖和代谢紊乱在全球范围内日益增多，与脑萎缩和功能障碍有关，而脑萎缩和功能障碍是晚年痴呆和阿尔茨海默病的危险因素。流行病学研究表明，生活方式的改变，包括经常进行体育锻炼，不仅能够预防和治疗肥胖/代谢紊乱，而且还能够改善认知功能和痴呆。已经提出了几种生化途径和表观遗传机制来理解体育锻炼对认知的有益影响。本文综述了运动引起的表观遗传机制的中枢研究进展及其对肥胖相关认知能力下降的有益影响，强调了潜在的机制性介导因素。
