Antigen- and lectin-sensitized murine cytolytic T lymphocyte-precursors require both interleukin 2 and endogenously produced immune (gamma) interferon for their growth and differentiation into effector cells.

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作者信息

Simon M M, Landolfo S, Diamantstein T, Hochgeschwender U

出版信息

Curr Top Microbiol Immunol. 1986;126:173-85. doi: 10.1007/978-3-642-71152-7_21.

DOI:10.1007/978-3-642-71152-7_21

PMID:3087705

Abstract

摘要

相似文献

Antigen- and lectin-sensitized murine cytolytic T lymphocyte-precursors require both interleukin 2 and endogenously produced immune (gamma) interferon for their growth and differentiation into effector cells.

Curr Top Microbiol Immunol. 1986;126:173-85. doi: 10.1007/978-3-642-71152-7_21.

Monoclonal antibodies to interferon-gamma inhibit interleukin 2-dependent induction of growth and maturation in lectin/antigen-reactive cytolytic T lymphocyte precursors.抗γ干扰素单克隆抗体可抑制凝集素/抗原反应性细胞毒性T淋巴细胞前体中白细胞介素2依赖性的生长和成熟诱导。

J Immunol. 1986 Apr 15;136(8):2755-62.

Interleukin 2 is both necessary and sufficient for the growth and differentiation of lectin-stimulated cytolytic T lymphocyte precursors.白细胞介素2对于凝集素刺激的细胞溶解性T淋巴细胞前体的生长和分化而言，既是必要的，也是充分的。

J Immunol. 1985 Mar;134(3):1644-52.

Signal requirements for the in vitro differentiation of cytotoxic T lymphocytes (CTL): distinct soluble mediators promote preactivation of CTL-precursors, clonal growth and differentiation into cytotoxic effector cells.细胞毒性T淋巴细胞（CTL）体外分化的信号要求：不同的可溶性介质促进CTL前体细胞的预激活、克隆生长以及分化为细胞毒性效应细胞。

Eur J Immunol. 1985 May;15(5):472-8. doi: 10.1002/eji.1830150511.

Rapid generation of potent and tumor-specific cytotoxic T lymphocytes by interleukin 18 using dendritic cells and natural killer cells.利用树突状细胞和自然杀伤细胞，通过白细胞介素18快速产生强效且肿瘤特异性的细胞毒性T淋巴细胞。

Cancer Res. 2000 Sep 1;60(17):4838-44.

Induction of cytolytic cells by pure recombinant human interleukin 2.纯重组人白细胞介素2诱导溶细胞性细胞

Eur J Immunol. 1984 Nov;14(11):1057-60. doi: 10.1002/eji.1830141118.

Interleukin 2 induces both, growth and maturation of lectin reactive Lyt-2+ but not Lyt-2-precursor cells and regulates the cytolytic potential of effector cells.白细胞介素2可诱导凝集素反应性Lyt-2+细胞而非Lyt-2-前体细胞的生长和成熟，并调节效应细胞的细胞溶解潜能。

Immunobiology. 1986 Apr;171(3):274-301. doi: 10.1016/S0171-2985(86)80010-9.

Regulation of cytotoxic lymphocyte precursors. II. The effect of interleukin-2 and interferon-gamma on the apparent specificity of effector cells.细胞毒性淋巴细胞前体的调控。II. 白细胞介素-2和γ干扰素对效应细胞表面特异性的影响。

Cell Immunol. 1986 Jun;100(1):239-46. doi: 10.1016/0008-8749(86)90023-7.

Requirement for three distinct lymphokines for the induction of cytotoxic T lymphocytes from thymocytes.从胸腺细胞诱导细胞毒性T淋巴细胞需要三种不同的淋巴因子。

J Immunol. 1986 Dec 1;137(11):3494-500.

Expression of heat-stable antigen on tumor cells provides co-stimulation for tumor-specific T cell proliferation and cytotoxicity in mice.肿瘤细胞上热稳定抗原的表达为小鼠体内肿瘤特异性T细胞的增殖和细胞毒性提供共刺激。

Eur J Immunol. 1995 May;25(5):1163-7. doi: 10.1002/eji.1830250505.

引用本文的文献

Simian virus 40 large-T-antigen-specific rejection of mKSA tumor cells in BALB/c mice is critically dependent on both strictly tumor-associated, tumor-specific CD8(+) cytotoxic T lymphocytes and CD4(+) T helper cells.在BALB/c小鼠中，猿猴病毒40大T抗原特异性排斥mKSA肿瘤细胞严重依赖于严格肿瘤相关、肿瘤特异性的CD8(+) 细胞毒性T淋巴细胞和CD4(+) T辅助细胞。

J Virol. 2001 Nov;75(22):10593-602. doi: 10.1128/JVI.75.22.10593-10602.2001.

Modulation by gamma interferon of antiviral cell-mediated immune responses in vivo.体内γ干扰素对抗病毒细胞介导免疫反应的调节作用

J Virol. 1996 Mar;70(3):1521-6. doi: 10.1128/JVI.70.3.1521-1526.1996.

Further characterization of protective Trypanosoma cruzi-specific CD4+ T-cell clones: T helper type 1-like phenotype and reactivity with shed trypomastigote antigens.克氏锥虫特异性保护性CD4 + T细胞克隆的进一步表征：1型辅助性T细胞样表型及与脱落型锥鞭毛体抗原的反应性

Infect Immun. 1993 Aug;61(8):3250-8. doi: 10.1128/iai.61.8.3250-3258.1993.

Interferon-gamma (IFN-gamma) production in vivo in experimental autoimmune uveoretinitis.实验性自身免疫性葡萄膜视网膜炎中体内γ干扰素（IFN-γ）的产生

Immunology. 1992 Mar;75(3):463-7.

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