使用枸杞补充剂治疗 12 个月可延缓视网膜色素变性的锥体细胞退化。

Delay of cone degeneration in retinitis pigmentosa using a 12-month treatment with Lycium barbarum supplement.

机构信息

Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR, China.

出版信息

J Ethnopharmacol. 2019 May 23;236:336-344. doi: 10.1016/j.jep.2019.03.023. Epub 2019 Mar 12.

DOI:10.1016/j.jep.2019.03.023

PMID:30877066

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Lycium barbarum L. (also known as "Goji berry"), a traditional Chinese herbal medicine, has been a common herb in the traditional Chinese pharmacopoeia for centuries. The main active component is the Lycium barbarum polysaccharides and its antioxidative effect has been widely shown to provide neuroprotection to the eye, and it would, therefore, be interesting to determine if Lycium barbarum help delay vision deterioration in patients with retinitis pigmentosa.

AIM OF THE STUDY

Cone rescue is a potential method for delaying deterioration of visual function in Retinitis pigmentosa (RP). This study aimed to investigate the treatment effect of Lycium barbarum L. (LB) supplement on retinal functions and structure in RP patients after a 12-month intervention trial.

METHODS

The investigation was a double-masked and placebo-controlled clinical study. Each of forty-two RP subjects who completed the 12-month intervention (23 and 19 in the treatment and placebo groups respectively) received a daily supply of LB or placebo granules for oral administration. The primary outcome was change of best corrected visual acuity (VA) (90% and 10% contrast) from the baseline to the end of treatment. The secondary outcomes were sensitivity changes of the central visual field, amplitude of full-field electroretinogram (ffERG) (including scotopic maximal response and photopic cone response), and average macular thickness.

RESULTS

The compliance rates for both groups exceeded 80%. There were no deteriorations of either 90% or 10% contrast VA in the LB group compared with the placebo group (p = 0.001). A thinning of macular layer was observed in the placebo group, which was not observed in the LB group (p = 0.008). However, no significant differences were found in the sensitivity of visual field or in any parameters of ffERG between the two groups. No significant adverse effects were reported in the treatment group.

CONCLUSIONS

LB supplement provides a neuroprotective effect for the retina and could help delay or minimize cone degeneration in RP.

CLASSIFICATIONS

Clinical Studies (1.05).

TRIAL REGISTRATION

clinicaltrials.gov Identifier NCT02244996.

摘要

民族药理学相关性

枸杞（俗称“枸杞果”）是一种传统的中药，在中国传统药典中已有数百年的应用历史。其主要活性成分为枸杞多糖，已广泛证明其具有抗氧化作用，能为眼部提供神经保护，因此，确定枸杞是否有助于延缓色素性视网膜炎患者的视力恶化将是一件很有趣的事情。

研究目的

视锥细胞挽救是延缓色素性视网膜炎（RP）患者视觉功能恶化的一种潜在方法。本研究旨在探讨枸杞（LB）补充剂对 RP 患者视网膜功能和结构的治疗效果，为期 12 个月的干预试验。

方法

该研究是一项双盲、安慰剂对照的临床研究。42 名完成 12 个月干预的 RP 患者（治疗组和安慰剂组各 23 名和 19 名）分别接受每日口服 LB 或安慰剂颗粒的治疗。主要结局是从基线到治疗结束时最佳矫正视力（VA）（90%和 10%对比度）的变化。次要结局是中央视觉领域的敏感性变化、全视野视网膜电图（ffERG）的振幅（包括暗视最大反应和明视锥反应）和平均黄斑厚度。