Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
REshape Center for Innovation, Radboud University Medical Center, Nijmegen, the Netherlands.
Diabetes Care. 2019 Apr;42(4):689-692. doi: 10.2337/dc18-1843.
Changes in heart rate variability (HRV) occur at the initiation of hypoglycemia due to sympathetic nervous system activity. We investigated the use of HRV detection by a wearable device as an early alert for hypoglycemia.
This proof-of-principle study included 23 patients with type 1 diabetes (14 women, mean age 42 ± 11 years). Patients wore a VitalConnect HealthPatch for 5 days. Hypoglycemia was defined as glucose ≤70 mg/dL (≤3.9 mmol/L) by fingerstick measurement. HRV was analyzed in standardized periods before the hypoglycemic event.
Sixty-six hypoglycemic events were recorded. Hypoglycemia caused a typical HRV pattern in 36 (55%) of the hypoglycemic events. Eighteen events (27%) showed an atypical pattern. Ten events were unclassified (15%), and two did not display a change in HRV (3%).
Hypoglycemia causes early changes in HRV that can be detected by a wearable device. Measuring real-time HRV seems promising for early hypoglycemia detection.
由于交感神经系统活动，在低血糖发生时，心率变异性（HRV）会发生变化。我们研究了使用可穿戴设备检测 HRV 作为低血糖早期预警的方法。
这是一项原理验证研究，纳入了 23 名 1 型糖尿病患者（14 名女性，平均年龄 42±11 岁）。患者佩戴 VitalConnect HealthPatch 长达 5 天。通过指尖测量，血糖≤70mg/dL（≤3.9mmol/L）定义为低血糖。在低血糖事件发生前的标准化时间段内分析 HRV。
记录到 66 次低血糖事件。低血糖导致 36 次（55%）低血糖事件中出现典型 HRV 模式。18 次（27%）显示非典型模式。10 次事件无法分类（15%），两次事件没有显示 HRV 变化（3%）。
低血糖会导致 HRV 的早期变化，可通过可穿戴设备检测到。实时测量 HRV 似乎是早期低血糖检测的有前途的方法。
