Genetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, MD, USA.
Epithelial Signaling and Transport Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
EMBO Rep. 2019 Apr;20(4). doi: 10.15252/embr.201947953. Epub 2019 Mar 15.
Oncogene‐dependent cancers upregulate and use lysosomal biogenesis for nutrient supply. It is unclear which lysosomal proteins and functions are essential for cell proliferation and tumor growth. A study by Jung in this issue of shows that increased levels of the lysosomal Ca release channel TRPML1 and its activator PI(3,5)P in HRAS ‐dependent tumors are essential for cell proliferation and tumor growth 1. Notably, genetic and pharmacological inhibition of TRPML1 is equally effective in suppressing HRAS ‐dependent tumors.
癌基因依赖性癌症上调并利用溶酶体生物发生来提供营养。目前尚不清楚哪些溶酶体蛋白和功能对于细胞增殖和肿瘤生长是必不可少的。Jung 在本期杂志中的一项研究表明，HRAS 依赖性肿瘤中溶酶体 Ca 释放通道 TRPML1 及其激活剂 PI(3,5)P 的水平升高对于细胞增殖和肿瘤生长是必需的 1。值得注意的是，TRPML1 的遗传和药理学抑制在抑制 HRAS 依赖性肿瘤方面同样有效。
