[云莓提取物对黑腹果蝇寿命和抗应激能力的影响。]

[The effects of cloudberry extract on Drosophila melanogaster lifespan and stress resistance.].

作者信息

Lashmanova E A, Kuzivanova O A, Dymova O V, Moskalev A A

机构信息

Institute of Biology of Komi Scientific Centre of the Ural Branch of RAS, 28 Kommunisticheskaya str., Syktyvkar, Komi Republic 167982, Russian Federation; e mail:

Moscow Institute of Physics and Technology, 9 Institutskiy per., Dolgoprudny, Moscow Region 141701, Russian Federation.

出版信息

Adv Gerontol. 2018;31(6):958-965.

PMID:30877828

Abstract

We have previously shown that carotenoids increase lifespan of model organisms Drosophila melanogaster and Caenorhabditis elegans. In the present study, we investigated the effects of cloudberry extract, an abundant food for people in North, with a relatively large carotenoid content on Drosophila melanogaster lifespan parameters and resistance to different stress conditions. It was shown that the cloudberry extract increased the median lifespan and the age of 90% mortality of females up to 11-19%. The rate of aging was decreased up to 13%. The effects of cloudberry extract on lifespan of males were less expressed. In some cases, they were even negative. The extract had no effects on males and females' resistance to starvation. However, it decreased the resistance of males to oxidative stress.

摘要

我们之前已经表明，类胡萝卜素可延长模式生物黑腹果蝇和秀丽隐杆线虫的寿命。在本研究中，我们调查了云莓提取物（北欧地区人们的一种常见食物，类胡萝卜素含量相对较高）对黑腹果蝇寿命参数以及对不同应激条件抵抗力的影响。结果表明，云莓提取物可使雌性果蝇的平均寿命和90%死亡率对应的年龄提高11% - 19%。衰老速率降低了13%。云莓提取物对雄性果蝇寿命的影响较小。在某些情况下，甚至呈现负面影响。该提取物对雄性和雌性果蝇的饥饿抵抗力没有影响。然而，它降低了雄性果蝇对氧化应激的抵抗力。