Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Key Laboratory of Micro-nano Measurement, Manipulation and Physics (Ministry of Education) & Department of Physics, Beihang University, Beijing, China.
Nanomedicine. 2019 Jun;18:272-281. doi: 10.1016/j.nano.2019.02.016. Epub 2019 Mar 14.
Radical therapy takes advantage of the reactive oxygen species produced in greater quantities within tumor cells than in normal cells. Here, for the first time, we explore a TiO nanoparticle mediated microwave induced radical therapy (termed as Microdynamic Therapy) as a new cancer treatment method. The experiments in vitro and in vivo demonstrate that colloidal TiO nanoparticles could significantly suppress the growth of osteosarcomas, even under low power (5 W) microwave (MW) irradiation for 5 min. The high photocatalytic activity of TiO nanoparticles efficiently utilizes the microwave-induced plasmonic effect for the formation of reactive oxygen species (ROS). Furthermore, TiO nanoparticles exhibit a higher cytotoxicity on cancer cells (osteosarcoma UMR-106 cells) than on normal cells (mouse fibroblast L929 cells). The effectiveness of TiO nanoparticles for microwave induced radical therapy demonstrates that this is a new landmark approach to treating cancers.
激进疗法利用肿瘤细胞内产生的大量活性氧物质，比正常细胞更多。在这里，我们首次探索了一种 TiO 纳米粒子介导的微波诱导自由基疗法（称为微动力疗法）作为一种新的癌症治疗方法。体外和体内实验表明，胶体 TiO 纳米粒子可以显著抑制骨肉瘤的生长，即使在低功率（5 W）微波（MW）照射 5 分钟的情况下也是如此。TiO 纳米粒子的高光催化活性有效地利用了微波诱导的等离子体效应来形成活性氧物质（ROS）。此外，TiO 纳米粒子对癌细胞（骨肉瘤 UMR-106 细胞）的细胞毒性高于正常细胞（小鼠成纤维细胞 L929 细胞）。TiO 纳米粒子用于微波诱导自由基疗法的有效性证明了这是一种治疗癌症的新的里程碑式方法。
