Serrano-Salazar M, Medina-Zahonero L, Janeiro-Marín D, Contreras-Lorenzo C, Aguilar-Pérez M, Sánchez-Sobrino B, López-Sánchez P, Ussetti-Gil P, Portoles-Perez J
Nephrology Department, H.U. Puerta de Hierro, Majadadonda, Spain.
Nephrology Department, H.U. Puerta de Hierro, Majadadonda, Spain; Public Research Net REDInREN 016/009/009 ISCIII, Majadahonda, Spain.
Transplant Proc. 2019 Mar;51(2):324-327. doi: 10.1016/j.transproceed.2018.10.016. Epub 2018 Oct 29.
The development of chronic kidney disease is a common complication after a lung transplantation, especially since the introduction of immunosuppressive treatments based on calcineurin inhibitors. Many of these patients reach end-stage renal disease and even need renal replacement therapy. Among the different options of renal replacement therapy, we consider kidney transplantation as a feasible option for these patients.
A single center, observational retrospective study including 8 lung transplanted patients who have received a kidney transplant in the period between 2013 and 2017 with at least 1 year of follow-up was used.
Seven patients maintained an adequate function of the graft 1 year after kidney transplantation, and 1 patient died because of a pulmonary condition in spite of a previous kidney transplant. Two patients presented delayed graft function in the first days after surgery.
The kidney transplantation is a technique of renal replacement therapy that should be considered in patients with previous lung transplantation. Experienced centers in double sequential lung and kidney transplantation should be established to assess and treat these types of patients.
慢性肾脏病的发展是肺移植术后常见的并发症，尤其是自从基于钙调神经磷酸酶抑制剂的免疫抑制治疗引入以来。这些患者中的许多人发展至终末期肾病，甚至需要肾脏替代治疗。在肾脏替代治疗的不同选择中，我们认为肾移植对这些患者来说是一种可行的选择。
采用一项单中心、观察性回顾性研究，纳入2013年至2017年期间接受肾移植且至少随访1年的8例肺移植患者。
7例患者肾移植术后1年移植肾功能良好，1例患者尽管之前接受了肾移植，但因肺部疾病死亡。2例患者术后早期出现移植肾功能延迟恢复。
肾移植是一种肾脏替代治疗技术，对于既往有肺移植的患者应予以考虑。应建立有经验的双序贯肺肾移植中心来评估和治疗这类患者。
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