Dupuis G, Vaugeois J-M
UFR Santé, département de pharmacie, 22, boulevard Gambetta, 76183 Rouen cedex 1.
Normandie University, université de Rouen, université de Caen, ABTE, 76000 Rouen, France; UFR Santé, département de pharmacie, 22, boulevard Gambetta, 76183 Rouen cedex 1.
Encephale. 2020 Feb;46(1):80-82. doi: 10.1016/j.encep.2019.01.006. Epub 2019 Mar 14.
Doxylamine (Donormyl®, Lidene®, Generics) is commonly proposed by pharmacists as a sleeping pill which does not require a prescription. In France, today it is only prescribed for occasional insomnia in adults. In light of knowledge about the role of the histamine H1 inverse agonist drugs in the treatment of insomnia, and specifically the low dose doxepin (3 mg and 6 mg) marketed in the US and Canada (Silenor®), we suggest that the use of doxylamine may be appropriate for treating insomnia in the last third of the night. Better information to the pharmacist on the prescription of this anti-H1 hypnotic would be beneficial to the patient.
多西拉敏（如多诺米、利登、通用名药物）通常被药剂师推荐为无需处方的安眠药。在法国，如今它仅被用于治疗成人偶尔出现的失眠。鉴于对组胺H1反向激动剂药物在失眠治疗中作用的了解，特别是美国和加拿大上市的低剂量多塞平（3毫克和6毫克，商品名：思诺思），我们认为多西拉敏可能适用于治疗后半夜的失眠。向药剂师提供有关这种抗H1催眠药处方的更多信息将对患者有益。
