医院抗菌药物管理项目的经济学影响：系统文献回顾。
The economic impact of antimicrobial stewardship programmes in hospitals: a systematic literature review.
机构信息
University of Greifswald, Chair of Health Care Management, Greifswald, Germany.
University of Greifswald, Chair of Health Care Management, Greifswald, Germany.
出版信息
J Hosp Infect. 2019 Aug;102(4):369-376. doi: 10.1016/j.jhin.2019.03.002. Epub 2019 Mar 14.
BACKGROUND
Antimicrobial stewardship programmes (ASPs) include strategies that enable sustainable management of rational anti-infective treatment in the clinical setting. The successful introduction of ASPs requires close interdisciplinary collaboration among various health professionals, including the hospital management. So far, ASPs have been evaluated mainly from a clinical-pharmacological and infectious disease perspective.
AIM
To identify and evaluate parameters with decisive significance for the economic impact of ASPs.
METHODS
A systematic literature search for peer-reviewed health-economic studies associated with antimicrobial stewardship programmes was performed. Primary outcomes included savings in drug costs and lower revenue losses for hospitals.
FINDINGS AND CONCLUSIONS
A total of 16 studies met all inclusion criteria. Most of the evidence from published clinical trials demonstrated savings through reduced direct cost of antibiotics. However, there are also studies that prove revenue effects of ASPs through decreases in length of stay and readmission rates.
背景
抗菌药物管理计划（ASPs）包括在临床环境中实现合理抗感染治疗可持续管理的策略。成功引入 ASP 需要包括医院管理层在内的各种卫生专业人员之间的密切跨学科合作。到目前为止，ASP 主要从临床药理学和传染病学的角度进行了评估。
目的
确定和评估对抗菌药物管理计划的经济影响具有决定性意义的参数。
方法
对与抗菌药物管理计划相关的同行评审卫生经济学研究进行了系统的文献检索。主要结果包括药物成本的节省和医院收入损失的降低。
结果和结论
共有 16 项研究符合所有纳入标准。大多数来自已发表临床试验的证据表明，通过减少抗生素的直接成本来节省费用。但是，也有研究证明 ASP 通过降低住院时间和再入院率来产生收入效应。
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