Hall D A, Crowley W F, Wierman M E, Simeone J F, McCarthy K A
J Clin Ultrasound. 1986 Jun;14(5):331-8. doi: 10.1002/jcu.1870140503.
Precocious puberty in young girls is defined as the development of secondary sexual characteristics and gonadal growth before 8 years of age. Approximately 60% of isosexual precocious development in girls has no organic cause and is termed idiopathic precocious puberty. Thirteen young girls with idiopathic precocious puberty were treated with LHRH analogue under a well-established protocol. Pelvic ultrasound was added to the protocol to examine ultrasound's role in supplying a morphologic parameter of suppression of the pubertal process. Initially, 11 patients had ovarian volumes greater than normal, and ovarian cysts measuring 0.5 cm to 4 cm in diameter were identified in seven patients. All 13 patients had enlarged pretreatment uteri greater than 3 cm in length. Eleven of these patients had a pubertal or adult uterine configuration. After 1 year of therapy, 11 patients had normal prepubertal ovarian volumes, and 12 of 13 patients had a decrease in ovarian volume. No demonstrable cysts were present at 1 year. Eleven had a reduction in uterine length. Nine of the 11 patients with a pubertal uterine configuration reverted to a more prepubertal-like morphology. The sonographic morphologic changes correlated well with laboratory and clinical data indicating suppression of the hypothalamic-pituitary-gonadal axis.
女童性早熟被定义为8岁前出现第二性征发育和性腺生长。女童同性性早熟中约60%无器质性病因，称为特发性性早熟。13例特发性性早熟女童按照既定方案接受促性腺激素释放激素（LHRH）类似物治疗。该方案增加了盆腔超声检查，以研究超声在提供青春期发育进程抑制的形态学参数方面的作用。最初，11例患者卵巢体积大于正常，7例患者发现直径为0.5 cm至4 cm的卵巢囊肿。所有13例患者治疗前子宫均增大，长度大于3 cm。其中11例患者子宫呈青春期或成人构型。治疗1年后，11例患者卵巢体积恢复至青春期前正常大小，13例患者中有12例卵巢体积减小。1年后未发现明显囊肿。11例患者子宫长度缩短。11例子宫呈青春期构型的患者中有9例恢复为更接近青春期前的形态。超声形态学变化与表明下丘脑-垂体-性腺轴受抑制的实验室和临床数据密切相关。
