胃动素1在胃癌中的作用及诊断潜力
The role and diagnostic potential of gastrokine 1 in gastric cancer.
作者信息
Koper-Lenkiewicz Olga M, Kamińska Joanna, Gawrońska Beata, Matowicka-Karna Joanna
机构信息
Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Białystok, Poland,
出版信息
Cancer Manag Res. 2019 Mar 1;11:1921-1931. doi: 10.2147/CMAR.S194949. eCollection 2019.
INTRODUCTION
Gene for () was identified as one of the most significant in gastric cancer and indicated as a potential therapeutic target.
AIM
The aim was a review of literature reports concerning the role and diagnostic potential of GKN1 in gastric cancer.
MATERIALS AND METHODS
PubMED database was searched for sources using the following keywords: gastrokine 1/GKN1/AMP-18 and gastric cancer, , aspirin, nonsteroidal anti-inflammatory drugs. Preference was given to the sources which were published within the past 10 years.
CONCLUSION
GKN1 is a stomach-specific protein, and its role consists of maintaining mucosal integrity as well as the replenishment of the surface lumen epithelial cells layer. The evaluation of GKN1 expression seems to be a useful indicator of the presence of neoplastic or inflammatory lesions in the gastric mucosa. GKN1 expression is decreased in gastric tumor tissues and derived cell lines and its upregulation in cell lines of gastric cancer induces cells apoptosis. The mechanism by which GKN1 is inactivated in gastric cancer cells is still not fully understood. The future diagnostic capabilities of gastric cancer concern the assessment of serum GKN1 concentration by means of ELISA method. Serum GKN1 concentration is not related to patients' sex. Moreover, the measurement of GKN1 concentration is possible only after the incubation of samples at 70°C for 10 minutes. Nevertheless, the aspect of quantitative serum GKN1 evaluation is new in the context of available literature and requires further studies.
引言
（）基因被确定为胃癌中最重要的基因之一，并被视为潜在的治疗靶点。
目的
目的是综述有关GKN1在胃癌中的作用和诊断潜力的文献报道。
材料与方法
在PubMed数据库中使用以下关键词搜索资料来源：胃动素1/GKN1/AMP-18与胃癌、、阿司匹林、非甾体抗炎药。优先选择过去10年内发表的资料来源。
结论
GKN1是一种胃特异性蛋白，其作用包括维持黏膜完整性以及补充表面腔上皮细胞层。评估GKN1表达似乎是胃黏膜中肿瘤性或炎性病变存在的有用指标。GKN1在胃肿瘤组织和衍生细胞系中的表达降低，其在胃癌细胞系中的上调诱导细胞凋亡。GKN1在胃癌细胞中失活的机制仍未完全了解。未来胃癌的诊断能力涉及通过ELISA方法评估血清GKN1浓度。血清GKN1浓度与患者性别无关。此外，只有在将样品在70°C孵育10分钟后才能测量GKN1浓度。然而，在现有文献的背景下，血清GKN1定量评估方面是新的，需要进一步研究。
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