Beck Jordan C, Lacker Caitlin R, Chapman Lauren M, Reisman Sarah E
The Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering , California Institute of Technology , Pasadena , CA 91125 , USA . Email:
Chem Sci. 2018 Dec 19;10(8):2315-2319. doi: 10.1039/c8sc05444d. eCollection 2019 Feb 28.
A modular synthesis of enantioenriched polyfunctionalized cyclobutanes was developed that features an 8-aminoquinolinamide directed C-H arylation reaction. The C-H arylation products were derivatized through subsequent decarboxylative coupling processes. This synthetic strategy enabled a 9-step enantioselective total synthesis of the antiproliferative meroterpenoid (+)-rumphellaone A.
开发了一种对映体富集的多官能化环丁烷的模块化合成方法，其特点是8-氨基喹啉酰胺导向的C-H芳基化反应。通过随后的脱羧偶联过程对C-H芳基化产物进行衍生化。这种合成策略实现了抗增殖半萜类化合物(+)-rumphellaone A的9步对映选择性全合成。
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