钯催化的烷基碳氢键转化反应
Palladium-Catalyzed Transformations of Alkyl C-H Bonds.
作者信息
He Jian, Wasa Masayuki, Chan Kelvin S L, Shao Qian, Yu Jin-Quan
机构信息
Department of Chemistry, The Scripps Research Institute , 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
出版信息
Chem Rev. 2017 Jul 12;117(13):8754-8786. doi: 10.1021/acs.chemrev.6b00622. Epub 2016 Dec 2.
Abstract
This Review summarizes the advancements in Pd-catalyzed C(sp)-H activation via various redox manifolds, including Pd(0)/Pd(II), Pd(II)/Pd(IV), and Pd(II)/Pd(0). While few examples have been reported in the activation of alkane C-H bonds, many C(sp)-H activation/C-C and C-heteroatom bond forming reactions have been developed by the use of directing group strategies to control regioselectivity and build structural patterns for synthetic chemistry. A number of mono- and bidentate ligands have also proven to be effective for accelerating C(sp)-H activation directed by weakly coordinating auxiliaries, which provides great opportunities to control reactivity and selectivity (including enantioselectivity) in Pd-catalyzed C-H functionalization reactions.
摘要
本综述总结了钯催化的通过各种氧化还原体系实现的C(sp)-H活化的进展，包括Pd(0)/Pd(II)、Pd(II)/Pd(IV)和Pd(II)/Pd(0)。虽然在烷烃C-H键活化方面报道的例子很少，但通过使用导向基团策略来控制区域选择性并构建合成化学的结构模式，已经开发出了许多C(sp)-H活化/C-C和C-杂原子键形成反应。许多单齿和双齿配体也已被证明可有效加速由弱配位助剂导向的C(sp)-H活化，这为控制钯催化的C-H官能化反应中的反应性和选择性（包括对映选择性）提供了巨大机遇。
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