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铜绿假单胞菌血流感染的抗生素治疗：疗程多久才足够？

Antibiotic Therapy for Pseudomonas aeruginosa Bloodstream Infections: How Long Is Long Enough?

作者信息

Fabre Valeria, Amoah Joe, Cosgrove Sara E, Tamma Pranita D

机构信息

Division of Infectious Diseases, Department of Medicine, Baltimore, Maryland.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

出版信息

Clin Infect Dis. 2019 Nov 13;69(11):2011-2014. doi: 10.1093/cid/ciz223.

DOI:10.1093/cid/ciz223
PMID:30882137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7320076/
Abstract

In a multicenter, observational, propensity-score-weighted cohort of 249 adults with uncomplicated Pseudomonas aeruginosa bacteremia, patients receiving short-course (median, 9 days; interquartile range [IQR], 8-10) therapy had a similar odds of recurrent infection or death within 30 days as those receiving longer courses (median, 16 days; IQR, 14-17).

摘要

在一项多中心、观察性、倾向评分加权队列研究中，纳入了249例无并发症的铜绿假单胞菌血症成人患者，接受短疗程（中位数为9天；四分位间距[IQR]为8 - 10天）治疗的患者在30天内发生反复感染或死亡的几率与接受长疗程（中位数为16天；IQR为14 - 17天）治疗的患者相似。

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JAMA Intern Med. 2019 Mar 1;179(3):316-323. doi: 10.1001/jamainternmed.2018.6226.
2
Seven Versus 14 Days of Antibiotic Therapy for Uncomplicated Gram-negative Bacteremia: A Noninferiority Randomized Controlled Trial.单纯革兰氏阴性菌菌血症患者接受 7 天与 14 天抗生素治疗的对比：一项非劣效性随机对照试验。
Clin Infect Dis. 2019 Sep 13;69(7):1091-1098. doi: 10.1093/cid/ciy1054.
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How to manage infections.如何控制感染。
Drugs Context. 2018 May 29;7:212527. doi: 10.7573/dic.212527. eCollection 2018.
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5
Association of Adverse Events With Antibiotic Use in Hospitalized Patients.住院患者不良事件与抗生素使用的关联
JAMA Intern Med. 2017 Sep 1;177(9):1308-1315. doi: 10.1001/jamainternmed.2017.1938.
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