囊性纤维化患儿肠道对[51Cr]乙二胺四乙酸的通透性

Intestinal permeability to [51Cr]EDTA in children with cystic fibrosis.

作者信息

Leclercq-Foucart J, Forget P, Sodoyez-Goffaux F, Zappitelli A

出版信息

J Pediatr Gastroenterol Nutr. 1986 May-Jun;5(3):384-7. doi: 10.1097/00005176-198605000-00008.

DOI:10.1097/00005176-198605000-00008

Abstract

Intestinal permeability was investigated in 14 children with cystic fibrosis making use of [51Cr]EDTA as probe molecule. Ten normal young adults and 11 children served as controls. After oral administration of [51Cr]EDTA, 24 h urine was collected. Urinary radioactivity was calculated and results expressed as percentage of oral dose excreted in 24 h urine. Mean and SEM were as follows: 2.51 +/- 0.21, 2.35 +/- 0.24, and 13.19 +/- 1.72 for control children, normal adults, and cystic fibrosis patients, respectively. The permeability differences between cystic fibrosis patients and either control children or control adults are significant (p less than 0.001).

摘要

利用[51Cr]乙二胺四乙酸（EDTA）作为探针分子，对14名囊性纤维化患儿的肠道通透性进行了研究。10名正常青年人和11名儿童作为对照。口服[51Cr]EDTA后，收集24小时尿液。计算尿放射性，并将结果表示为24小时尿液中排泄的口服剂量的百分比。对照组儿童、正常成年人和囊性纤维化患者的平均值和标准误分别如下：2.51±0.21、2.35±0.24和13.19±1.72。囊性纤维化患者与对照组儿童或对照组成年人之间的通透性差异具有显著性（p<0.001）。