动脉血气张力对去脑大鼠血管紧张素II升压反应的影响。
The effects of arterial blood gas tensions on pressor responses to angiotensin II in the pithed rat.
作者信息
Grant T L, McGrath J C
出版信息
J Physiol. 1986 Mar;372:437-44. doi: 10.1113/jphysiol.1986.sp016018.
The influence of arterial blood gas tensions on angiotensin II-mediated pressor responses in the pithed rat was studied by altering the inspired gas mixture at a fixed tidal volume. When rats were ventilated to produce physiological Pa, CO2 levels (35-40 mmHg) responses to boluses of angiotensin II were greater with increasing Pa, O2 over the Pa, O2 range of 65-460 mmHg. There was no difference in response to angiotensin II over the Pa, CO2 range studied (18-50 mmHg). All variations in response to angiotensin II were attributable to changes in Pa, O2. Since arterial blood gas tensions, especially the Pa, O2, modulate pressor responses to boluses of angiotensin II, the physiological effects of this hormone may be most fruitfully explored in rats ventilated to produce normal arterial blood gas tensions.
通过在固定潮气量下改变吸入气体混合物，研究了动脉血气张力对去大脑大鼠血管紧张素II介导的升压反应的影响。当大鼠通气以产生生理Pa,CO₂水平（35 - 40 mmHg）时，在65 - 460 mmHg的Pa,O₂范围内，随着Pa,O₂升高，对血管紧张素II推注的反应增强。在所研究的Pa,CO₂范围（18 - 50 mmHg）内，对血管紧张素II的反应没有差异。对血管紧张素II反应的所有变化都归因于Pa,O₂的变化。由于动脉血气张力，尤其是Pa,O₂，调节对血管紧张素II推注的升压反应，因此在通气以产生正常动脉血气张力的大鼠中，可能最有效地探索这种激素的生理作用。
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