Zibo Vocational Institute, Zibo, Shandong 255314, China.
Department of Breast and Thyroid Surgery, Zibo Central Hospital, Zibo, Shandong 255036, China.
Cancer Biomark. 2019;24(3):269-277. doi: 10.3233/CBM-182216.
Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts that play important roles in tumorigenesis and tumor progression. Our study aimed to explore the role of lncRNA MAGI2-AS3 in breast cancer metastatic progression. In the present study, our results showed that MAGI2-AS3 can inhibit the migration and invasion of breast cancer cells. In addition, an increase in MAGI2-AS3 can inhibit microRNA-374a (miR-374a) expression in breast cancer cells. Bioinformatic analysis predicted the correlation between MAGI2-AS3 and miR-374a. Phosphatase and tensin homolog (PTEN) was found to be an novel mRNA target of miR-374a. MAGI2-AS3 upregulation inhibited breast cancer metastatic progression by decreasing miR-374a and enhancing PTEN expression. Together, our data revealed that lncRNA MAGI2-AS3 is involved in breast cancer cell progression by regulating the miR-374a-PTEN axis. These findings offer new insight into treatment strategies for breast cancer.
长链非编码 RNA（lncRNA）是一类不编码蛋白质的转录本，在肿瘤发生和肿瘤进展中发挥重要作用。我们的研究旨在探索 lncRNA MAGI2-AS3 在乳腺癌转移进展中的作用。在本研究中，我们的结果表明 MAGI2-AS3 可以抑制乳腺癌细胞的迁移和侵袭。此外，MAGI2-AS3 的增加可以抑制乳腺癌细胞中 microRNA-374a（miR-374a）的表达。生物信息学分析预测了 MAGI2-AS3 与 miR-374a 之间的相关性。发现磷酸酶和张力蛋白同源物（PTEN）是 miR-374a 的一种新型 mRNA 靶标。MAGI2-AS3 的上调通过降低 miR-374a 和增强 PTEN 表达来抑制乳腺癌转移进展。总之，我们的数据表明，lncRNA MAGI2-AS3 通过调节 miR-374a-PTEN 轴参与乳腺癌细胞的进展。这些发现为乳腺癌的治疗策略提供了新的见解。
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